This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research.
Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques.
A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS
assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans
presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters
examines the multidrug resistance protein P-glycoprotein as a natural transporter
analyzes current drug designs to known requirements for transport
looks at drug delivery systems for the brain
and much more!
Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.
Table of Contents
History and Physiology of the Blood-Brain Barrier in Relation to Delivery of Drugs to the Brain
Michael W. Bradbury
Physicochemical Factors that Influence Brain Uptake
Michael H. Abraham and James A. Platts
The Development of In Vitro Models for the Blood-Brain and Blood-CSF Barriers
Christiane Engelbertz, Dorothea Korte, Thorsten Nitz, Helmut Franke, Matthias Haselbach, Joachim Wegener, and Hans-Joachim Galla
In Vitro Models of the Blood-Brain Barrier and Their Use in Drug Development
R. Cecchelli, B. Dehouck, L. Descamps, L. Fenart, V. Buée-Scherrer, C. Duhem, G. Torpier, and M. P. Dehouck
The Application of Microdialysis Techniques to the Study of Drug Transport Across the Blood-Brain Barrier
A. G. de Boer, Elizabeth C. M. de Lange, Inez C. J. van der Sandt, and Douwe D. Breimer
The Role of Brain Extracellular Fluid Production and Efflux Mechanisms in Drug Transport to the Brain
David J. Begley, Anthony Regina, Françoise Roux, Ehsan Ullah Khan, Christopher Rollinson, and Joan Abbott
The Relevance of P-Glycoprotein in Drug Transport to the Brain: The Use of Knockout Mice as a Model System
Specific Mechanisms for Transporting Drugs Into Brain
Drug Metabolism in the Brain: Benefits and Risks
Alain Minn, Ramon D. S. El-Bachá, Claire Bayol-Denizot, Philippe Lagrange, Funmilayo G. Suleman, and Daniela Gradinaru
Targeting Macromolecules to the Central Nervous System
Using Nanoparticles to Target Drugs to the Central Nervous System
Jörg Kreuter and Renad N. Alyautdin
Basic CNS Drug Transport and Binding Kinetics In Vivo
Albert Gjedde, Antony D. Gee, and Donald Frederick Smith