The Adrenal Medulla, 1989-1991 offers a comprehensive review of the world literature on the adrenal medulla published during this period. The book emphasizes the role of the adrenal medulla in advancing our knowledge of neuroscience; for example, the Nobel Prize-winning technique of patch clamping has been applied to stimulus-secretion coupling in adrenal chromaffin cells.
The book also discusses such topics as the ability to image the distribution of calcium within individual neural cells, the ability to measure individual packets of neurotransmitter as they are released from cells, and advances in the understanding of ionic channels, cell-to-cell interactions, cell proliferation, sympathoadrenal ontogeny, growth factors, enzymatic biosynthetic pathways, electron and proton transfer, and neural pathways. Topics covered in clinical medicine include recent progress in the transplantation of the adrenal medulla to the brain as a treatment for Parkinson's disease and the latest reports on pheochromocytoma.
The Adrenal Medulla, 1989-1991 is an essential book for neurobiologists, neurochemists, experimental biologists, physiologists, cell biologists, and informed clinicians.
Table of Contents
OVERVIEW. MORPHOLOGY. Comparative Morphology. Development. Descriptions and Alterations. Endothelium and Circulation. Innervation. ENZYMES. Tyrosine Hydroxylase. Aromatic L-Amino Acid Decarboxylase. Dopamine B-Hydroxylase. Phenylethanolamine N-Methyl-Transferase. General Aspects of Catecholamine Synthesizing Enzymes. Adenosine Triphosphatase (ATPase). Monoamine Oxidase. Nitric Oxide Synthase. Acetylcholinesterase. Other Enzymes. COMPOSITION OF THE CHROMAFFIN CELL. Amines. Chromogranins. Comparisons to Composition of Sympathetic Terminals. Composition of Chromaffin Vesicles. Composition of Chromaffin Cells. Composition of PC12 Cells. Molecules in the Adrenal Medulla. PEPTIDES. Opioid Peptides. Other Peptides. STIMULUS-SECRETION COUPLING: RECEPTORS. General Aspects of Stimulus-Secretion Coupling. Nicotinic Receptors. Muscarinic Receptors. g-Aminobutyric Acid (GABA) Receptors. Dopaminergic Receptors. Purinergic Receptors. Substance P. Natriuretic Peptide and Other Peptide Receptors. Adrenergic Receptors. Histamine Receptors. Angiotensin II. Electrical Stimulation. Endothelin Receptors. Prostaglandin Receptors. Receptor-Specific Inhibitors. Other (Novel) Ligands. STIMULUS-SECRETION COUPLING: SECOND MESSENGERS, IONS. Calcium Channels. Sodium Channels. Potassium Channels. pH. General Considerations. STIMULUS-SECRETION COUPLING: OTHER SECOND MESSENGERS. Calcium-Binding Proteins. Nucleotides and Binding Proteins. Cytoskeleton and Contractile Proteins. Protein Kinases. Phospholipases. Toxins. STIMULUS-SECRETION COUPLING: EXOCYTOSIS. EFFECTS OF DRUGS. 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) and 1-Methyl-4-Phenylpyridinium (MPP+). Ethanol. Analgesics and Drugs of Abuse. Anesthetics. Antihypertensives. "Traditional" Medicine. Organophosphates and Pollutants. Viruses. Amine Metabolism. Other Considerations. UPTAKE MECHANISMS. Uptake into Cells. Uptake into Chromaffin Vesicles. NEURAL CONTROL. Central Nervous System Control of the Adrenal Medulla. Intermediolateral Cell Column and Preganglionic Fibers. Postganglionic Innervation of the Adrenal Gland. Other Neurogenic and Non-Neurogenic Mechanisms of Functional Regulation. GROWTH FACTORS. Nerve Growth Factor. Basic Fibroblast Growth Factor. Insulin-Like Growth Factor. Other Factors. Other Molecular Biology Aspects. Other Considerations. PSYCHOLOGY. Stress. Memory. Mental Health. PHYSIOLOGY. Cardiovascular System. Hypoxia. Exercise. Regulation of Blood Glucose. Diabetes. Renal Physiology. Perinatal Physiology. Aging. Circadian Rhythms. Temperature Regulation. Interactions with other Endocrine Organs. Other Considerations. TRANSPLANTATION. Clinical Experience. Autopsy Findings in Adrenal-Caudate Transplant Patients. Animal Studies. CELL CULTURE. CLINICAL CONSIDERATIONS. Pheochromocytoma. Imaging. Neuroblastoma and Ganglioneuroma. Adrenal Medullary Hyperplasia. Adrenal Hemorrhage. Diabetes. Other Clinical Considerations. BIBLIOGRAPHY. AUTHOR INDEX. SUBJECT INDEX.
Catalog no. 4449
January 1993, ISBN: 0-8493-4449-2
U.S. $00.00/Outside U.S. $00.00
I highly recommend this book as a convenient and comprehensive reference source, bothe for researchers currently working with chromaffin cells and for those unfamiliar with the field.
ARTHUR S. TISCHLER, M.D., TUFTS UNIVERSITY SCHOOL OF MEDICINE