Medulla transplantationStimulus-secretion couplingNeuropeptidesEnzymes of catecholamine biosyntesisGrowth factorsNeural regulation and clinical considerations
This volume provides a complete review of all the articles which have appeared in the literature since 1986 that pertain to the adrenal medulla and adrenal chromaffin. Over 1700 articles are reviewed, organized, and summarized. Topics covered include the transplantation of medulla into the brain, stimulus-secretion coupling, neuropeptides, enzymes of catecholamine biosynthesis, growth factors, neural regulation and clinical considerations, including imaging and tumors. This book will provide interesting reading for neurobiologists, cell biologists, pathologists, diagnostic radiologists, and advanced biology students.
Table of Contents
DEDICATION. ACKNOWLEDGEMENTS. TERMINOLOGY. PREFACE. OVERVIEW. MORPHOLOGY. Comparative Morphology. Developmental Studies. Morphologic Descriptions and Alterations. STIMULUS-SECRETION COUPLING: RECEPTORS. Nicotinic Receptors. Desensitization. Muscarinic Receptors. Adrenergic Receptors. Dopaminergic Receptors. c-Aminobutyric Acid (GABA) Receptors. Opioid Peptide Receptors. Atrial Natriuretic Factor Receptors. Other Peptide Receptors. Other Receptors. STIMULUS-SECRETION COUPLING: IONS. Calcium Ions. Sodium. Other Ions. STIMULUS-SECRETION COUPLING: INTRACELLULAR PROTEINS AND NUCLEOTIDES. Calcium Binding Proteins. Cytoskeleton and Contractile Proteins. Protein Kinases. Nucleotides. GTP-Binding Proteins. Phospholipases. Other Proteins. STIMULUS SECRETION COUPLING: EXOCYTOSIS. Techniques. Osmotic Forces. Membrane Retrieval. Other Considerations. EFFECTS OF DRUGS. MPTP. Ethanol. Anesthetics. Other Agents. ENZYMES. Tyrosine Hydroxylase. Aromatic L-Amino Acid Decarboxylase. Dopamine b-Hydroxylase. Phenylethanolamine N-Methyltransferase. Other Enzymes. COMPOSITION OF THE CHROMAFFIN CELL. Amines. Chromogranins. Lipids and Related Substances. Other Constituents. PEPTIDES. Enkephalins and Related Peptides. Neuropeptide Y. Other Peptides. Regulation and Processing. UPTAKE MECHANISMS. Uptake into Chromaffin Vesicles. Uptake into Chromaffin Cells. NEURAL REGULATION. Intermediolateral Cell Column and Preganglionic Fibers. Effects of Insulin and Role of Sensory Afferents. Central Nervous System Stimulation and Lesion. Monoaminergic and Cholinergic Systems in the CNS. Peptidergic and Other Systems in the CNS. GROWTH FACTORS. Nerve Growth Factor Receptors. Effects of Nerve Growth Factor. Interactions Between Nerve Growth Factor and Other Factors. Other Growth Factors. CELL CULTURE. TRANSPLANTATION. Animal Models. Clinical Trials. Other Considerations. PSYCHOLOGY. Stress and Emotional Behavior. Age. Memory. Stress Induced Analgesia, Chronic Stress, and Indices of Sympathoadrenal Function. Interaction with Pituitary Hormones and Peptides. PHYSIOLOGY. Perinatal Physiology. Exercise. Temperature Regulation. Digestive Physiology, Feeding and Drinking. Renal Physiology. Interactions with Other Endocrine Organs. Cardiovascular System. Effects of Drugs and Neurotransmitters on Blood Pressure. Ethanol. Aging. Other Physiologic Effects. CLINICAL CONSIDERATIONS. Imaging. Pheochromocytomas. Other Considerations. BIBLIOGRAPHY. AUTHOR INDEX. SUBJECT INDEX. c. 536 pp., 1989, ISBN 0-9369-2328-8.