Welcome to CRCPress.com! We have customized the Taylor & Francis India website to host CRC Press titles. Please choose www.TandFIndia.com to get the following benefits:
South Asia Editions of CRC Press titles with INR prices
Multiple options to purchase locally
All CRC Press products available
Your CRC Press login credentials will work on TandFIndia.com
Garland Science Website Announcement
The Garland Science website is no longer available to access and you have been automatically redirected to CRCPress.com.
All instructor resources are now available on our Instructor Hub. Your GarlandScience.com instructor credentials will not grant access to the Hub, but existing and new users may request access here.
The student resources previously accessed via GarlandScience.com are no longer available to existing or new users.
Please accept our apologies for any inconvenience this may cause.
This textbook serves as a comprehensive reference on the latest science underlying the development of biological therapies, as well as their use in animal and human studies of rheumatological disease. Part A covers targets of emerging therapies - targeting/manipulating cells, targeting cell surface receptors, targeting cytokines, inflammatory mediators and transcription factors, and targeting plasma molecules. Part B then examines the use and implementation of these new therapies in the clinic, covering their use in treating specific rheumatological conditions. Part C discusses issues relating to study design and regulatory issues in the US and Europe.
Table of Contents
Part A. Targets. Section I: Targeting/Manipulating Cells. T-cells. B-cells. Macrophages. Dendritic cells. Neutrophils. Fibroblasts. Mast Cells. Section II: Targeting Cell Surface Receptors. Complement Receptors. Fc-Receptors. CD-28. Fas. Section III: Targeting Cytokines. TNF-alpha. IL-1. IL-6. IL-18. IL-12. IL-15. Th1/Th2 balance a) Experimental models of rheumatological diseases b) Human disease. OPG. Chemokines. The balance between pro- and anti- inflammatory cytokines. Section IV. Targeting Inflammatory Mediators and Transcription Factors. iNOS. COX/PG synthases. Matrix molecules. NFkB. Jak/STATs. MMPs. Angiogenesis. Section V: Targeting. Immunoglobulins. Complement. Apheresis. Part B. Studies in Human and Experimental Rheumatic Diseases. Ethical Issues. Rheumatoid Arthritis. Biologics in Early Arthritis. Juvenile Arthritis. Psoriatic arthritis/psoriasis. Spondylarthritis. Systemic Lupus Erythematosus. Vasculitis. Myositis. Part C. Study Design. Randomized Controlled Trials. Long-Term Observational Studies. Long-Term Monitoring of Experimental (Novel) Therapies. Community-Based Studies. Regulatory Issues - FDA Index. Section II: Targeting Cell Surface Receptors. Section III: Targeting Cytokines. Section IV: Targeting Inflammatory mediators and Transcription Factors.
'...the immense value of this book lies in its ability to convey a target-directed approach to management of the rheumatic diseases. It is this type of perspective that represents the future of practice in the field of immune-mediated diseases and in medicine in general.' - Doodys Publishing Review
'...this book is superior to the general textbooks in both the depth of information provided on the subject of targeted therapies and the range of relevant topics that are discussed.' - American College of Physicians
We provide complimentary e-inspection copies of primary textbooks to instructors considering our books for course adoption.
CPD consists of any educational activity which helps to maintain and develop knowledge, problem-solving, and technical skills with the aim to provide better health care through higher standards. It could be through conference attendance, group discussion or directed reading to name just a few examples.
Use certain CRC Press medical books to get your CPD points up for revalidation. We provide a free online form to document your learning and a certificate for your records.