This book offers an explanation of the specific ways that biocatalysis outperforms chemical catalysis by: utilizing ambient temperature and atmospheric pressure to minimize problems of isomerization, racemization, and epimerization; employing microbial cells and enzymes that can be immobilized and reused over many cycles; and overexpressing enzymes for greater economy and efficiency.
Table of Contents
Stereoselective synthesis using hydantoinases and carbamoylases; aminoacidase-catalyzed preparation and further transformations of enantiopure alpha-hydrogen- and alpha,alpha-disubstitute alpha-amino acids; chemoenzymatic synthesis of pheromones, terpenes and other bioregulators; stereoselective biocatalysis for synthesis of some chiral pharmaceutical intermediates; stereoselective hydroxylation reactions; regio- and stereoselective microbial hydroxylation of terpenoid compounds; microbial epoxidation - application in biotechnology; stereoselective syntheses using microbial epoxide hydrolases; enzymatic asymmetric synthesis using aldolases; decarboxylases in stereoselective catalysis; biocatalysis in the enantioselective formation of chiral cyanohydrins, valuable building blocks in organic synthesis; hydroxynitrile lyases in stereoselective synthesis; production of chiral beta-hydroxy acids and its application in organic syntheses; stereoselective synthesis of chiral compounds using whole-cell biocatalysis; choice of biocatalyst in the development of industrial biotransformations; chiral synthons by enzymatic acylation and esterification reactions; stereoselective nitrile-covering enzymes; enzyme-mediated decarboxylation reactions in organic synthesis; yeast-mediated stereoselective biocatalysis; biocatalytic synthesis of steroids; biocatalytic synthesis of enantiopure compound using lipases; chemoenzymatic preparation of enantiomerically pure S(+)-2-arylpropionic acids with anti-inflammatory activity; biocatalytic production of pravastatin, an antiocholesterol drug; application of PEG-modified enzymes in biotechnological processes; new avenues to high-performance immobilized biosystems - from biosensors to biocatalysts; enzymatic protecting group techniques in organic synthesis; enzymatic reactions in supercritical carbon dioxide; dehydrogenases in the synthesis of chiral compounds; stereoselective microbial Baeryer-Villiger oxidations.
". . .a welcome addition to the shelves of medicinal chemicals, microbiologists, and biochemical engineers laboring in the pharmaceutical, agrochemical and food industries to synthesize chiral products.... . . .an excellent book."
---Journal of Medicinal Chemistry
"...an excellent text covering all aspects of biocatalysis for the synthesis of chiral compounds. It is an invalauble source book for both academic and industrial researchers with interests in biotransformations."
---Journal of the American Chemical Society
"...a good reference source for specialists working in the field."
---Journal of Natural Products
"...a welcome addition to the library anyone who is working in the field or wishes to take an in-depth look at the very exciting new developments in this area."
---Angewandte Chemie, 2001