Structure of Antigens discusses a variety of topics dealing with the structural basis of antigenicity. Topics include the analytical methods used to elucidate the structure of antigens, the structure of antibodies, the principles underlying modern immunoassays and the measurement of antibody binding affinity, and physicochemical principles and methodological aspects. The book also considers major groups of antigens distinguished by their functional activity and biological role (e.g., drugs, autoantigens, snake toxins, allergens) or by their association with particular biological systems (e.g., antigens of microorganisms).
Structure of Antigens will provide a current, useful, reference for researchers and graduate students in all fields of biological science who need an overview of antigenic specificity.
Table of Contents
Molecular Dissection of Protein Antigens (Marc H. V. Van Regenmortel). Structure of Protein Epitopes Deduced from X-Ray Crystallography (Eduardo A. Padlan). Antigen Mimicry with Synthetic Peptides (S. Vuilleumier and M. Mutter). Antigen Mimicry with Anti-Idiotypic Antibodies (Neil S. Greenspan). Prediction of T-Cell-Recognized Epitopes in Proteins (Shan Lu, Victor E. Reyes, Christopher M. Bositis, Thomas G. Goldschmidt, Valery Lam, Christopher H. Sorli, Rochelle R. Torgerson, Robert A. Lew, and Robert E. Humphreys). Antigen-Antibody Reactions (Carel J. van Oss). Measurement of Antibody Affinity (Robert Karlsson, Daniele Altschuh, and Marc H.V. Van Regenmortel). Maturation of the Immune Response (Claudia Berek). Immunoadjuvants (Arlette Adam and Vongthip Souvannavong). Precipitation and Agglutination (Carel J. van Oss). The Behavior of Antigens and Antibodies Immobilized on a Solid Phase (John E. Butler). Drugs as Antigens (Johan Hoebeke and A. Donny Strosberg). Snake Toxins as Antigens (André Ménez, Laurence Pillet, Michel Léonetti, François Bontems, and Bernard Maillere). Antibody Subclasses (Roy Jefferis). Histocompatibility Antigens (Béatrice Perarnau, Hélene Gournier, Claude Barra, Razqallah Hakem, and François A. Lemonnier). Vaccine Antigens (Gordon L. Ada).
415 pp., 6x9, 1992, ISBN 0-8493-8865-1.