Synergy is the key to creating more intelligent biosensors. Engineers develop smaller, more integrated technologies; biologists and chemists develop increasingly selective and sensitive sensor elements; material scientists develop ways to bring it all together. However, most books focus only on the chemistry aspects of biosensor technologies. With a multidisciplinary perspective, Smart Biosensor Technology examines the design, applications, and future directions of this rapidly evolving field.
This book collects contributions from leading specialists in a variety of scientific and engineering disciplines involved in different aspects of biosensor design and technology. Five broad sections provide a systematic structure that builds progressively from key concepts to emerging technologies and future directions. Following an introduction to the fundamental characteristics and functions of the underlying technologies, two sections explore the role materials play in developing smart biosensors. Next, the editors devote an entire section to bioelectronics with a focus on a biophotonic material called bacteriorhodopsin and its application to photoelectric biosensing, chemical sensing, and color imaging. They also present design and fabrication of new bioelectronic sensing arrays on flexible substrates. The final section explores a variety of smart biosensor applications in detecting food pathogens, monitoring toxicity, and detecting allergens and viruses.
Building a solid background in the underlying technologies and demonstrating how to apply this knowledge to solve real problems, Smart Biosensor Technology is a comprehensive, interdisciplinary guide to extending the capabilities of biosensors for a broad range of fields.
Table of Contents
OVERVIEW AND FUNDAMENTALS
Toward Understanding the Intelligent Properties of Biological Macromolecules-Implications for Their Design into Biosensors; Kenneth A. Marx
Optical Methods of Single Molecule Detection and Applications in Biosensors; Xiaomeng Wang, Melissa Massey, Paul A.E. Piunno, and Ulrich J. Krull
Nanoscale Optical Biosensors and Biochips for Cellular Diagnostics; Brian M. Cullum
Conducting Polymer Nanowire-Based BioFET for Label-Free Detection; Adam K. Wanekaya, Wilfred Chen, Nosang V. Myung, and Ashok Mulchandani
Smart Biosensor Functions-A Machine Learning Perspective; George K. Knopf
Neuronal Network Biosensors; Guenter W. Gross and Joseph J. Pancrazio
MATERIAL DESIGN AND SELECTION I
Material Design and Selection for Smart Biosensors; Amarjeet S. Bassi
Molecular Film Assembled Detection System for Biosensors by Layer-by-Layer Adsorption; Shin-ichiro Suye and Haitao Zheng
Nanostructured Organic Matrices and Intelligent Sensors; Claudio Nicolini, Manuela Adami, and Cristina Paternolli
The Challenge of Human Skin-Engineering the Biotic/Abiotic Interface; Puneet Khanna, Steven Hoath, Rod Smallwood, and Shekhar Bhansali
MATERIAL DESIGN AND SELECTION II
Porous Silicon in Biosensing Applications; Benjamin L. Miller
Fundamental Aspects and Applications of Nanotubes and Nanowires for Biosensors; Xueliang Sun and Chen-zhong Li
Electrochemical Biosensors Based on Carbon Nanotubes; Won-Yong Lee
Bacteriorhodopsin: From Biophotonic Material to Chemical Sensor; Jeffrey A. Stuart, Robert R. Birge, Pallab Bhattacharia, Brian J. Yordy, Jeffrey Girard, William Tetley, Duane L. Marcy, Jeremy F. Koscielecki, and Jason R. Hillebrecht
Photoelectric Biosensors: Fundamentals and Innovative Designs; Felix T. Hong
Color-Sensitive Biosensors for Imaging Applications; Lasse Lensu, Michael Frydrych, Jussi Parkkinen, Sinikka Parkkinen, and Timo Jaaskelainen
Protein-Based Photoreceptor Array on Flexible Plastic Substrates; Wei Wei Wang, George K. Knopf, and Amarjeet S. Bassi
APPLICATIONS IN DETECTION AND MONITORING
Optical Biosensors in Foodborne Pathogen Detection; Tao Geng and Arun K. Bhunia
Multiarray Biosensors for Toxicity Monitoring and Bacterial Pathogens; Silvana Andreescu, Jason Karasinski, and Omowunmi A. Sadik
Approaches to Allergy Detection Using Aptasensors; Emile Brys, Sara Tombelli, Maria Minunni, Marco Mascini, and Anthony P.F. Turner
Biosensors for Virus Detection; Ebtisam S. Wilkins and Ravil A. Sitdikov
Detection of Hanta, Influenza A, and Parainfluenza Virus; Ebtisam S. Wilkins and Ravil A. Sitdikov
Perspectives on Biosensor Technology; Amarjeet S. Bassi and George K. Knopf
"Much remains to be done before smart biosensors advance to the point where they have more global comparative advantage. Thus, the present volume is both timely and important as it will further research and interaction among the groups working in this important field. … The chapters included in this volume provide an excellent introduction to and perspective on current research and developments in biosensors."
-From the foreword by Dr. Robert R. Birge, University of Connecticut, Storrs, USA