Signaling by Toll-Like Receptors

Gregory W. Konat

June 20, 2008 by CRC Press
Reference - 224 Pages - 2 Color & 19 B/W Illustrations
ISBN 9781420043181 - CAT# 43188
Series: Methods in Signal Transduction Series


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  • Describes approaches to evaluate cellular response to TLR stimulation
  • Addresses an important issue regarding the choice of ligands for such studies
  • Discusses events along the intracellular signaling pathways
  • Explores the role of toll-like receptors in tissue injury and neurodegeneration
  • Examines recombinant stratagems to study interactions of TLRs with other signaling proteins and mechanisms
  • Addresses the interplay of TLR signaling with other pathophysiological processes
  • Summary

    The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.