Signal Transduction in Leukocytes: G Protein-Related and Other Pathways

1st Edition

Pramod M. Lad, John S. Kaptein, Ching-Kow Lin

CRC Press
Published November 27, 1995
Reference - 400 Pages
ISBN 9780849366949 - CAT# 6694

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Summary

Signal Transduction in Leukocytes presents important principles and various aspects of cellular regulation in leukocytes. The book discusses receptor structure and signaling, emphasizing cytokine receptors and the T cell and B cell antigen receptors. It investigates the role of the heterotrimeric G proteins and small G proteins as transducers.
Authorities in each field cover a wide range of topics. They explore propagation of signaling cascades through second messengers and serine/threonine kinases, the initiation of signaling from the B and T cell antigen receptors by tyrosine phosphorylation and protein recruitment, and the role of signaling in cell-cell interactions and the regulation of the cell cycle. The book outlines the relationship of receptor signaling to inflammatory reactions of neutrophils, eosinophils, and macrophages.

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