Focusing on what has been one of the driving forces behind the development of lab-on-a-chip devices, Separation Methods in Microanalytical Systems
explores the implementation, realization, and operation of separation techniques and related complex workflows on microfabricated devices. The book details the design, manufacture, and integration of diverse components needed to perform an entire analytical procedure on a single miniaturized device. The content applies to a diversity of disciplines including chemical analysis, biomedical diagnostics, environmental monitoring, and drug discovery.
Separation Methods in Microanalytical Systems lays its theoretical background in a way that scientists from varied disciplines can approach. The book describes factors that influence the performance of separation, such as microfluidic handling, sample pre-treatment, and detection. It also conveys fabrication and material issues, design challenges, and practical considerations. Several chapters describe specific separation techniques that are central to micro-Total Analysis Systems (µ-TAS) as well as novel methods and emerging trends in microchip-based separations. The book also provides an applications overview that supplies a wealth of examples that help scientists put their ideas in perspective with already existing solutions.
This multi-authored volume offers different styles, approaches, and opinions for a given problem, reflecting the various angles researchers take to handle the same issues. A one-stop guide for understanding, designing, and working with separation techniques in microanalytical devices, Separation Methods in Microanalytical Systems is a valuable reference for scientists and engineers already preparing to meet the anticipated demand for function-specific chemical separation systems.
Table of Contents
Analytical Microsystems: A Bird’s Eye View; C.S. Effenhauser
Microfluidics: Some Basics; S.C. Jacobson and C.T. Culbertson
Microfabrication and Integration; J.G.E. Gardeniers and A. van den Berg
New Tools: Scalar Imaging, Velocimetry, and Simulation; E.F. Hasselbrink, Jr. and S. Madhavan-Reese
Transport Modes: Realizations and Practical Considerations; S.R. Wallenborg, P. Andersson, and G. Thorsén
Pressure-Driven Separation Methods on a Chip; G. Desmet, E. Chmela, and R. Tijssen
Transverse Transport in Microsystems: Theory and Applications; P. Yager, C. Cabrera, and A. Kamholz
Electro-Driven Separation Methods on Chips; R.P.H. Nikolajsen, G.S. Chirica, Y. Fintschenko, and J.P. Kutter
Gas Chromatography on Microchips; R.J. Kottenstette, C.-N.C. Wong, and C.D. Mowry
Sample Preparation on Microchips; J. Lichtenberg, S. Koster, L. Ceriotti, N.F. de Rooij, and E. Verpoorte
Detection on Microchips: Principles, Challenges, Hyphenation, and Integration; S. Pasas-Farmer, B. Fogarty, B. Huynh, N. Lacher, B. Carlson, R.S. Martin, W. Vandaveer III, and S. Lunte
Analytical Applications on Microchips; S. Liu and V. Dolnik Index
“This is just what I have been looking for. To my knowledge it’s the first time that anyone has put together a definitive book on the subject... The editors have done an excellent job in ensuring that the authors keep to their brief and do not cover data or examples give by other authors, but [still] have allowed the authors their individual styles... it is [of] great value, a book every researcher and student should have.”
— P. Myers, in Chromatographia, 2006, vol. 63