Scaffolding In Tissue Engineering

Peter X. Ma, Jennifer Elisseeff

August 19, 2005 by CRC Press
Reference - 656 Pages - 241 B/W Illustrations
ISBN 9781574445213 - CAT# DK3367


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  • Lays the fundamental principles behind reconstructing biologically functional tissues and organs
  • Brings together a large number of experts in engineering, life sciences, and clinical medicine with various tissue engineering expertise
  • Evaluates the latest materials and their biological interaction
  • Studies how synthetic materials are manufactured
  • Describes how scaffold structure can be modified to perform a specific biological function
  • Surveys the various kinds of tissue that synthetic materials can replicate or regenerate
  • Summary

    The growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering.

    Scaffolding in Tissue Engineering reviews the general principles of tissue engineering and concentrates on the principles, methods, and applications for a broad range of tissue engineering scaffolds. The first section presents an in-depth exploration of traditional and novel materials, including alginates, polysaccharides, and fibrillar fibrin gels. The following section covers fabrication technologies, discussing three-dimensional scaffold design, laboratory-scale manufacture of a cell carrier, phase separation, self-assembly, gas foaming, solid freeform fabrication, injectable systems, and immunoisolation techniques. Subsequent chapters examine structural and functional scaffold modification, composite scaffolds, bioactive hydrogels, gene delivery, growth factors, and degradation of biodegradable polymers. The final section explores various tissue engineering applications, comprising chapters on blood cell substitutes, and tissue engineering of nerves, the tendons, ligaments, cornea, cartilage and myocardium, meniscal tissue.

    While providing a comprehensive summary of current knowledge and technologies, Scaffolding in Tissue Engineering gives readers insight into new trends and directions for scaffold development and for an ever-expanding range of tissue engineering applications.