1st Edition

Sarcopenia Molecular, Cellular, and Nutritional Aspects – Applications to Humans

Edited By Dominique Meynial-Denis Copyright 2020
    454 Pages 8 Color & 42 B/W Illustrations
    by CRC Press

    454 Pages 8 Color & 42 B/W Illustrations
    by CRC Press



    Sarcopenia: Molecular, Cellular, and Nutritional Aspects describes the progressive loss of skeletal muscle mass and strength, defined by Rosenberg in 1997 as a hallmark of aging and referred to as “sarcopenia”. As life expectancy continues to increase worldwide, sarcopenia has become a major public health issue. The condition worsens in the presence of chronic diseases that accelerate its progression. Sarcopenia is not considered to be “a process of normative aging” but according to the International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM), as a disease. As sarcopenia is an unavoidable process, prevention and management are the only options to promote healthy aging, actions that should perhaps should perhaps be taken during youth.



    Included in this book:



    ·       Features essential information on sarcopenia, its current definition, and molecular and cellular aspects of this disease



    ·       Discusses the development of physical frailty, a complication of sarcopenia, and predicts its occurrence in the older population



    ·       Presents alterations in muscle protein turnover and mitochondrial dysfunction in the aging process 



    ·       Provides data on the negative involvement of sarcopenia in certain chronic diseases that can lead to cachexia, a metabolic wasting syndrome



    ·       Describes presbyphagia or age-related changes in the swallowing mechanism in older people



    ·       Details possible strategies to combat muscle wasting in healthy older adults and their limitations



    This book features information collected from pioneers or experts on human aging from around the globe, including Europe, Brazil, Canada, Japan and the United States. It is a valuable source of information for nutritional scientists, medical doctors, sports scientists, food scientists, dietitians, students in these fields, and for anyone interested in nutrition. We hope this book provides a better understanding of sarcopenia which inevitably occurs with aging without weight loss. The book also provides information outlining strategies to prevent or limit muscle wasting due to normal aging in order to promote successful aging.



     

    Introduction

    Naji Abumrad

    Section 1: Basics of sarcopenia: definition and challenges of sarcopenia research

    Chapter 1 Definitions of Sarcopenia

    Heike Bischoff-Ferrari and Bess Dawson-Hughes

    Section 2: New data on sarcopenia

    Chapter 2 Models of Accelerated Sarcopenia

    Andrew S. Layne, Lisa M. Roberts and Thomas W. Buford

    Chapter 3 Sarcopenia in physical frailty

    Maturin Tabue-Teguo, Emanuele Marzetti, Riccardo Calvani et al.

     

    Section 3: Molecular and cellular aspects of sarcopenia

    Chapter 4 The role of imaging techniques in the diagnosis of sarcopenia

    Thiago Gonzalez Barbosa-Silva and Carla Prado

    Chapter 5 Nutrient Sensing and mTORC1 Regulation in Sarcopenia

    Ted G. Graber and Blake B. Rasmussen

    Chapter 6 Different adaptation of ubiquitin-proteasome and lysosome-autophagy signaling in sarcopenic muscle

    Kunihiro Sakuma and Hidetaka Wakabayashi

    Chapter 7 Myokines in aging muscle

    Katie Brown, Aaron Persinger and Melissa Puppa

    Chapter 8 The contribution of satellite cells to skeletal muscle aging

    Christopher Fry

    Chapter 9 Muscle stem cell microenvironment in sarcopenia

    Neia Naldaiz-Gastesi and Ander Izeta

    Chapter 10 Sarcopenia and Oxidative stress: from the bench to therapeutical strategies

    Coralie Arc-Chagnaud, Allan F. Pagano and Thomas Brioche

    Section 4: Alterations in muscle protein turnover in the aging process

    Chapter 11 Muscle protein turnover and sarcopenia in the elderly: the effects of nutrition

    Paolo Tessari

    Chapter 12 The relationship between muscle mitochondrial turnover and sarcopenia

    Heather N. Carter, Nashwa Cheema and David A. Hood

    Chapter 13 Skeletal muscle fat infiltration with aging: an important factor of sarcopenia

    Allan F. Pagano, Coralie Arc-Chagnaud and Thomas Brioche et al.

     

    Section 5: Recent advances limiting sarcopenia and supporting healthy aging

    Chapter 14 Nutritional modulation of mitochondrial-associated death signaling in sarcopenia

    Stephen E. Alway

    Chapter 15 Beneficial effects and limitations of strategies (nutritional or other) to limit muscle wasting due to normal aging

    Dominique Meynial-Denis

     

    Section 6: Applications

    Part 1: Muscle impairments or diseases due to the frailty induced by sarcopenia

    Chapter 16 Declines in whole muscle function with aging: the role of age-related alterations in contractile properties of single skeletal muscle fibres

    Nicole Mazara and Geoffrey A. Power

    Chapter 17 Sarcopenic dysphagia, presbyphagia and rehabilitation nutrition

    Hidetaka Wakabayashi and Kunihiro Sakuma

    Part 2: Complications due to sarcopenia in acute or chronic diseases

    Chapter 18 Wasting and cachexia in chronic kidney disease

    Giacomo Garibotto, Daniela Picciotto and Daniela Verzola

    Chapter 19 Sarcopenia and Parkinson's disease: molecular mechanisms and clinical management

    Manlio Vinciguerra

    Chapter 20 Sarcopenic obesity in the elderly

    Michael Tieland, Inez Trouwborst, Amely Verreijen et al

    Chapter 21 Sum up and future research

    Dominique Meynial-Denis

    Biography

    Dominique Meynial-Denis studied Biochemistry and Molecular Biology at the University Paul Sabatier of Toulouse, France and obtained her Ph.D. degree on intermolecular interactions between drug and plasma proteins followed by magnetic resonance spectroscopy (MRS) at the same University in 1985. Since 1986, she has worked as a scientist at the National Institute of Agricultural Research (INRA) in Clermont-Ferrand in a Department focussing on Human Nutrition. Consequently, she became a Nutritionist and specialised her research on Sarcopenia and Aging in 1994. She applied MRS to metabolic pathways of amino acids in muscle during aging. Dominique Meynial-Denis received a second Ph.D. in 1998 on amino acid fluxes throughout skeletal muscle during aging. More recently, she has mainly been interested in the effect of glutamine supplementation in advanced age. She is a member of the French Society of Enteral and Parenteral Nutrition (SFNEP), of the European Society of Clinical Nutrition and Metabolism (ESPEN), of the Société Française de Nutrition (SFN), of the International Association of Gerontology and Geriatrics (IAGG) and of the Société Francophone de Gérontologie et Gériatrie (SFGG). She is a regular referee to different international journals on Nutrition as well as Aging.

    'This book reflects the evolving research on sarcopenia and its fundamental applications. The purpose is to present a comprehensive review of research in the field of sarcopenia. Instead of having to read through hundreds of journal articles on sarcopenia, readers can find a chapter with up-to-date summaries of evidence-based medicine and research in this book.

    'Physicians, medical students, nutritionists, and non-clinical sarcopenia researchers will find this book helpful. It is written at a high scientific
    level and expects readers have baseline knowledge of sarcopenia. The author and contributors write at a level for their colleagues or peers. The chapters on molecular and cellular aspects of sarcopenia are challenging but eye opening for clinicians who do not work in lab settings. The chapters on clinical findings and management will be more readily understood by all. The result is a well-rounded, applicable knowledge of sarcopenia, brought to life by leading international sarcopenia researchers.

    'No other sarcopenia book on the market that I have read compares to this one. It is comprehensive but not overwhelming, futuristic but applicable. The most unique feature is the author's ability to link multiple scientific disciplines from molecular biology to nutrition to explain one of the most prevalent and destructive syndromes in aging.'

    Weighted Numerical Score: 88 - 3 Stars

    -- Issam el bizri, Dartmouth Geisel School of Medicine