Rhabdomyosarcoma is one of the most common malignant solid tumors of children and adolescents. This book provides a comprehensive review of current knowledge and addresses the many complex issues in the diagnosis and treatment of the tumor. It represents the results of 15 years of research by the Intergroup Rabdomyosarcoma Study, which is a large, multi-national, collaborative project that has made significant progress in elucidating the epidemiological, biological, and clinical characteristics of these malignancies. All researchers, pediatricians, and other physicians who work with Rhabdomyosarcoma will find an incredible amount of valuable information in this book.
Table of Contents
TUMOR BIOLOGY AND HISTOLOGY. Introduction: Epidemiology of Soft Tissue Sarcomas (Frederick Ruymann and Seymour Grufferman). Pathology of Rhabdomyosarcoma and Related Tumors: Experience of the Intergroup Rhabdomyosarcoma Studies (William A. Newton, Ala Hamoudi, Bruce Webber, and Paul S. Dickman). Biology of Rhabdomyosarcoma: Cell Culture, Xenografts, and Animal Models (Paul S. Dickman, Maria Tsokos, and Timothy J. Triche). CLINICAL MANIFESTATIONS AND DIAGNOSIS OF RHABDOMYOSARCOMA. Rhabdomyosarcoma in Children: Clinical Symptoms, Diagnosis, and Staging (Francoise Flamant, Bernard Luboinski, Dominique Conanet, and Heither McDowell). Diagnostic Imaging of Rhabdomyosarcoma (Lakshmana Das Narla and James W. Walsh). Prognostic Factors in Rhabdomyosarcoma (Lisa A. Garnsey and Edmund A. Gehan). TREATMENT. Pharmacologic Considerations and New Agent Therapy (Robert L. Saylors, III and Teresa J. Vietta). Surgical Principles in the Management of Sarcomas in Children (Walter Lawrence, Jr.). Radiation Therapy Guideline in Rhabdomyosarcoma: Results of Intergroup Rhabdomyosarcoma Studies (Melvin Tefft). Drug Sensitivity and Resistance in the Xenograft Model (Peter Houghton, Julie K. Horton, and Janet Houghton). Chemotherapy for Previously Untreated Patients with Rhabdomyosarcoma (Harold M. Maurer and William Crist). Disseminated Intravascular Coagulopathy, Hypercalcemia, and Hyperuricemia in Rhabdomyosarcoma (Frederick B. Ruymann and Paul Thomas). Results of Treatment of Rhabdomyosarcoma in the European Studies (Joern Treuner, Francoise Flamant, and Modesto Carli). Novel Therapeutic Strategies for the Treatment of Rhabdomyosarcoma and Soft Tissue Sarcomas: Preliminary Results with Intra-Arterial Chemotherapy and DNA Manipulation of the Cell Cycle (Norman Jaffe, Marija Ausersperg, Olga Porenta, Marija Us-Krasovec, W. Gohde, and J. Lanovec). Patterns of Treatment Failure and the Meaning of Complete Response in Rhabdomyosarcoma (Modesto Carli and Giorgia Perilongo). Evaluation and Treatment of Relapsed Rhabdomyosarcoma (James Miser). Late Effects of Therapy in Rhabdomyosarcoma (Ruth Heyn). SPECIFIC SITES OF INVOLVEMENT. Rhabdomyosarcoma and Related Tumors of the Head and Neck in Childhood (R. Beverly Raney). Rhabdomyosarcoma of the Gastrointestinal Tract (Jorge Ortega and Marcio Malogolowkin). Genitourinary Rhabdomyosarcoma (Fereshteh Ghavimi). Rhabdomyosarcoma in Extremity and Trunk Sites (Eugene S. Wiener and Daniel M. Hays). Rhabdomyosarcomas in Infancy (Ray C. Pias and Abdelsalam H. Ragab). Pathology of Soft Tissue Sarcomas in Children and Adolescents (Paul E. Swanson and Louis D. Dehner). Clinical Manifestations and Treatment of Soft Tissue Sarcomas Other Than Rhabdomyosarcoma (Charles B. Pratt). Index.