Revival: Spheroid Culture in Cancer Research (1991)

1st Edition

Rolf Bjerkvig

CRC Press
December 31, 2018 Forthcoming
Reference - 344 Pages
ISBN 9781138561908 - CAT# K43497
Series: CRC Press Revivals

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Summary

Spheroid Culture in Cancer Research describes the various techniques now available for establishing spheroid tissue culture, including spheroid culture from normal tissues and from tumor cell lines. The book also describes how the spheroid system can be used to study interactions between normal and malignant cells. Microenvironmental conditions in spheroids and how this micromilieu may promote cellular heterogeneity and histiotypic structures not observed in corresponding monolayer cultures are discussed. The biological importance of oxygen tension, pH gradients, diffusions of nutrients, and cell-cell communication in spheroids are also examined.

The book will be profoundly important to researchers in experimental chemotherapy, radiotherapy, immunotherapy, and hyperthermia.

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