Radiotracers in Drug Development

Graham Lappin, Simon Temple

April 3, 2006 by CRC Press
Reference - 320 Pages - 7 Color & 105 B/W Illustrations
ISBN 9780849333477 - CAT# 3347

USD$253.00

Add to Wish List
FREE Standard Shipping!

Features

  • Describes the theory and practice behind the detection and measurement of radioactivity using scintillation counting
  • Covers the principles of radioactive decay and measuring of radioactivity
  • Discusses how to measure low levels of tracers with accelerator mass spectrometry
  • Explores how radiotracers are applied to the conduct of drug metabolism studies, both in vitro and in vivo
  • Presents examples and illustrations to show how the collected data is used in drug research
  • Highlights the radionuclide imaging techniques of gamma-scintigraphy and single-photon emission computed tomography
  • Summary

    Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers.

    The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry, positron emission tomography, gamma-scintigraphy, and radioluminography. In addition to describing how the analytical technologies work, the contributors explain how the data are interpreted and used in the drug registration process.

    A unique reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this is the only comprehensive, interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.

    Share this Title