Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of current cancer therapies.
Up to date, clearly organized, and thorough-sure to become a standard in the field!
Providing comprehensive treatment on radiolabeled antibody therapy, Radioimmunotherapy of Cancer
reviews dosimetric principles and clinical dosimetry of radioimmunotherapy in the targeting and delivery of radiation
describes tumor architectures and outlines novel constructs for radionuclide delivery
analyzes a variety of improved targeting approaches, including pretargeting contextual analysis of extracorporeal techniques in radioimmunotherapy
details studies from the radiotherapy of lymphoma, solid tumors, and ovarian cancer and the targeted radiotherapy of neuroblastoma and squamous head and neck cancer
and much more!
With contributions from nearly 50 international experts and containing over 1300 literature references, drawings, photographs, tables, and equations, Radioimmunotherapy of Cancer is an invaluable and indispensable reference for physicians in nuclear medicine and medical physicists; oncologists, radiologists, radiochemists, and radiopharmacists; immunologists, pulmonologists, and cancer researchers; pharmacologists and drug delivery pharmaceutical chemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
Table of Contents
Radionuclides for Radioimmunotherapy
Dosimetric Principles of Targeted Radiotherapy
Joseph A. O'Donoghue
Radionuclide Dosimetry and Radioimmunotherapy of Cancer
Ruby F. Meredith, Donald J. Buchsbaum, and Susan J. Knox
Metallic Radionuclides for Radioimmunotherapy
Alan R. Fritzberg and Claude F. Meares
Radiohalogens for Radioimmunotherapy
Michael R. Zalutsky
Delivery of Radiation to Tumors
Tumor Architecture and Targeted Delivery
Harold F. Dvorak, Janice A. Nagy, Dian Feng, and Ann M. Dvorak
Antibodies and Novel Constructs for Tumor Targeting
Dale C. Slavin-Chiorini, Patricia Horan Hand, and John W. Greiner
Pretargeted Radioimmunotherapy of Cancer
Marco Chinol, Chiara Grana, Roberto Gennari, Marta Cremonesi, J. G. Geraghty, and Giovanni Paganelli
Evolution of a Pretarget Radioimmunotherapeutic Regimen
Louis J. Theodore, Alan R. Fritzberg, Jody E. Schultz, and Donald B. Axworthy
Extracorporeal Techniques in Radioimmunotherapy
Sven-Erik Strand, Jan G. Tennvall, Hans-Olov Sjögren, JianQing Chen, Michael Garkavij, Cecilia Hindorf, Rune Nilsson, and Bengt E. B. Sandberg
Targeted Radiotherapy of Cancer
Radioimmunotherapy in the Treatment of Non-Hodgkin's Lymphoma
Monica S. Krieger, Paul L. Weiden, O. Press, G. L. DeNardo, and Hazel B. Breitz
Radioimmunotherapy of Solid Tumors
Hazel B. Breitz, Paul L. Weiden, and Paul L. Beaumier
Intraperitoneal Radioimmunotherapy of Ovarian Cancer
Konstantinos N. Syrigos and Agamemnon A. Epenetos
Targeted Radiotherapy in the Treatment of Osteosarcoma: Radiobiological Basis, Clinical Status, and Future Prospects
Øyvind S. Bruland and Alexander Pihl
Targeted Radiotherapy of Neuroblastoma
Cornelis A. Hoefnagel
Targeted Radiotherapy of Squamous Head and Neck
Guus A. M. S. van Dongen, Frank B. van Gog, Ruud H. Brakenhoff, Jasper J. Quak, Remco de Bree, Gerard W. M. Visser, and Gordon B. Snow
From the Foreword…
The past two decades have provided an opportunity for investigators to explore the capacity of monoclonal antibodies and other targeting molecules to deliver therapeutic doses of radiation via radioisotope conjugates. This book assembles a strong cast of these investigators to review the progress that has been made and to clarify the challenges that remain.
"-Albert F. Lobuglio, M.D.
Director, Comprehensive Cancer Center
Associate Dean, School of Medicine
Evalina B. Spencer Professor of Oncology
University of Alabama at Birmingham
...a clear, complete and outstanding report of the current status of radioimunotherapy....
...highly recommended to nuclear medicine residents, but it also serves a solid review of radioimmunotherapy for physicians who have been in this field for many years.
-Tijdschrift voor Nucleaire Geneeskunde, 2000
"…collects different contributions from the most important investigators in the field….
…important….very sharp and interesting.