Q fever is a zoonotic infectious disease caused by Coxiella burnetii, which infects a broad range of hosts. This volume presents critical reviews of the biological aspects of C. burnetii. Topics covered include C. burnetii's place in the microbial world through a comparison with other microorganisms that are phylogenetically related or share phenotypic traits; intrinsic properties of Coxiella with respect to infectivity, virulence, and pathogenecity; past and current methods for the isolation, amplification, and purification of C. Burnetii; obligate acidophily; metabolic capabilities, with emphasis on intermediary metabolism, macromolecular synthesis, and protein export; and human immune responses to bacterial components during acute and chronic infection by C. Burnetii. Other fascinating topics about C. Burnetii include antigens, virulence factors, and biological response modifiers; ultrastructure; genetics; cloning and expression; and C. burnetii in the U.S.S.R. and China. Epidemiologists, molecular biologists, microbiologists, and other researchers interested in Q fever and C. burnetii should consider this book an essential reference resource.
Table of Contents
The Place of Coxiella burnetii in the Microbial World (Dr. E. Weiss, Dr. J.C. Williams, and Dr. H.A. Thompson). Infectivity, Virulence, and Pathogenicity of Coxiella burnetii for Various Hosts (Dr. J.C. Williams). Methods for the Isolation, Amplification, and Purification of Coxiella burnetii (Dr. D.M. Waag, Dr. J.C. Williams, M.G. Peacock and Dr. D. Raoult). pH and Membrane Physiology in Coxiella burnetii (Dr. H.A. Thompson and Dr. J.C. Williams). Metabolism in Coxiella burnetii (Dr. H.A. Thompson). Immune Responses of Humans to Coxiella burnetii: Specific Antibody and Cell-Mediated Responses After Vaccination or Infection (Dr. D.M. Waag, C.R. Bolt, Dr. T.J. Marrie, and Dr. J.C. Williams). Antigens, Virulence Factors, and Biological Response Modifiers of Coxiella burnetii: Strategies for Vaccine Development (Dr. J.C. Williams and Dr. D.M. Waag). The Developmental Cycle of Coxiella burnetii (Dr. T.F. McCaul). The Genetics of Coxiella burnetii: Etiologic Agent of Q Fever and Chronic Endocarditis (Dr. L. Mallavia, Dr. J.E. Samuel and Dr. M.E. Frazier). Cloning and Expression of Coxiella burnetii DNA (Dr. T. Hoover and Dr. M. Vodkin). Q Fever Studies in the U.S.S.R. (Dr. T. Khavkin). Coxiella burnetii in China (Dr. Yu Shurong).