This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.
Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching.
New to the Fourth Edition:
- reorganized sections that cover basic principles followed by sections on different types of toxicity
- extensive use of examples throughout and numerous explanatory diagrams
- new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more
- questions with answers for each chapter for review and self-checking
- expanded and updated chapter bibliographies
An Introduction to Epigenetics
Manel Esteller
Epigenetics and Cancer: DNA Methylation
Santiago Ropero and Manel Esteller
Epigenetics and Cancer: Histone Modifications
Mario F Fraga and Manel Esteller
Epigenetic Drugs: DNA Demethylating Agents
Ehab Atallah and Guillermo Garcia-Manero
Epigenetic Drugs: Histone Deacetylase Inhibitors
Melissa Peart and Ricky W Johnstone
Sirtuins in Biology and Disease
Alejandro Vaquero and Danny Reinberg
MicroRNAs in Cell Biology and Diseases
Muller Fabbri, Carlo M Croce, and George A Calin
Chromatin Modifications by Polycomb Complexes
Miguel Vidal
Epigenetics and its Genetic Syndromes
Richard J Gibbons
Epigenetics and Immunity
Esteban Ballestar and Bruce Richardson
Etiology of Major Psychosis: Why Do We Need Epigenetics?
Gabriel Oh and Arturas Petronis
Epigenetics and Cardiovascular Disease
Gertrud Lund and Silvio Zaina
Plant Epigenetics
Mónica Meijón, Luis Valledor, Jose Luis Rodríguez,
Rodrigo Hasbún, Estrella Santamaría, Isabel Feito,
Maria Jesús Cañal, Maria Berdasco, Mario F Fraga,
and Roberto Rodríguez
Epigenetics, Environment, and Evolution
Douglas M Ruden, Parsa Rasouli, and Xiangyi Lu
Epigenetics and Epigenomics
José Ignacio Martín-Subero and Reiner Siebert
Index
An Introduction to Epigenetics
. Epigenetics and Cancer: DNA Methylation. Epigenetics and Cancer: Histone Modifications. Epigenetic Drugs: DNA Demethylating Agents. Epigenetic Drugs: Histone Deacetylase Inhibitors. Sirtuins in Biology and Disease. MicroRNAs in Cell Biology and Diseases. Chromatin Modifications by Polycomb Complexes. Epigenetics and its Genetic Syndromes. Epigenetics and Immunity. Etiology of Major Psychosis: Why Do We Need Epigenetics?. Epigenetics and Cardiovascular Disease. Plant Epigenetics. Epigenetics, Environment, and Evolution Epigenetics and Epigenomics. Index.Biography
John A. Timbrell