1st Edition
Preservation of Human Oocytes From Cryobiology Science to Clinical Applications
Oocyte cryopreservation entails important potential advantages for human
IVF, offering a less ethically disputable alternative to embryo cryopreservation,
simplifying and making safer oocyte donation, and giving an opportunity for
fertility preservation to women at risk of premature ovarian failure as an effect
of genetic factors or chemo- or radiotherapies. Oocyte cryopreservation could
also meet the expectations of women wishing to preserve their fertility for
social reasons. In the last few years, advances in cryopreservation
methodologies have dramatically improved the efficiency of oocyte
cryopreservation, leading to the birth of over a thousand babies and
challenging the supremacy of embryo cryopreservation as the preferred
form of fertility preservation. This text has been conceived with the aim of offering a comprehensive view of the state of the art of oocyte cryopreservation. It covers fundamental concepts of low temperature storage (controlled rate slow cooling and
vitrification), aspects of oocyte physiology relevant to the process of
cryopreservation, essential biological and clinical evidence, and ethical
implications of oocyte cryopreservation, thereby providing a complete
overview of progress in this strategy in assisted reproduction.
FUNDAMENTAL CRYOBIOLOGY
A Historical Overview of Embryo and Oocyte Preservation in the World of Mammalian In Vitro Fertilization and Biotechnology
Nucharin Songsasen and Pierre Comizzoli
Principles of Cryopreservation
David E. Pegg
The Rational Basis for Controlled Rate Slow Cooling
Barry Fuller and Sharon Paynter
Fundamentals and Current Practice of Vitrification
Lilia L. Kuleshova
Predictive Models for the Development of Improved Cryopreservation Protocols for Human Oocytes
John McGrath
BIOLOGICAL ASPECTS OF OOCYTE CRYOPRESERVATION
The Natural Life Cycle of the Mammalian Oocyte
David F. Albertini and S. Darlene Limback
Essential features of the mature oocyte
Ursula Eichenlaub-Ritter
Expression of Functional Aquaporins in Oocytes and Embryos and the Impact on Cryopreservation
François Chauvigné and Joan Cerdà
Oocyte Storage at Different Developmental Stages
Mafalda Rato and Carlos E. Plancha
Oocyte Cryopreservation in the Mouse
Maureen J. Wood
Oocyte Storage in Domestic Species
Gábor Vajta, Jason Conceicao, and John Yovich
Control of the Solution Effect During Controlled-Rate Cooling: Principles and Practical Application
James J. Stachecki
Cryopreservation and the Cytoskeleton of the Human Oocyte
Giovanni Coticchio and Maria Antonietta Bonu
Non-invasive Assessment of Cryopreserved Oocytes Through Polarized Light Microscopy
Markus Montag, Maria Köster, Benjamin Rösing, Katrin van der Ven, Hans van der Ven
Impact of Cryopreservation on Oocyte Physiology, Metabolism and the Proteome
Mark G. Larman and David K. Gardner
LABORATORY, CLINICAL, AND ETHICAL ASPECTS OF OOCYTE STORAGE
Quality Management of a Low Temperature Storage Program in the Human IVF Laboratory
Lucia De Santis
The Contribution of Embryo Cryopreservation to the Clinical Efficacy of ART and to a Reduction of ART Multiple Pregnancies
Karl G. Nygren
Factors Influencing the Clinical Efficiency of Oocyte Cryopreservation
Debra A. Gook and David H. Edgar
The Early and Recent History of Oocyte Cryopreservation in Human IVF
Eleonora Porcu, Leonardo Notarangelo, Antonia Bazzocchi, Chiara Landolfo, and Stefano Venturoli
Success Rates from Oocyte Cryopreservation
Andrea Borini and Maria Antonietta Bonu
Clinical Evidence of Oocyte Vitrification
Ri-Cheng Chian and Yin-Xia Cao
Oocyte Storage for Fertility Preservation Before Radio- and Chemotherapy
Michael von Wolff
The Impact of Oocyte Storage in Oocyte Donation Treatments
Ana Cobo and José Remohí
The Health of Children from Cryopreserved Oocytes and Embryos
Audrey Soo and Alastair Sutcliffe
The Ethics of Fertility Preservation
Carlo Flamigni
Biography
Andrea Borini, Giovanni Coticchio
