Preclinical and Clinical Modulation of Anticancer Drugs

1st Edition

Kenneth D. Tew, Peter J. Houghton, Janet A. Houghton

CRC Press
Published September 15, 1993
Reference - 384 Pages
ISBN 9780849372919 - CAT# 7291
Series: Handbooks in Pharmacology and Toxicology

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Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.


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