Practical Guide to ChIP-seq Data Analysis

1st Edition

Borbala Mifsud, Kathi Zarnack, Anaïs F Bardet

CRC Press
Published November 5, 2018
Reference - 100 Pages - 10 B/W Illustrations
ISBN 9781138596528 - CAT# K387449
Series: Focus Computational Biology Series

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Summary

Chromatin immunoprecipitation sequencing (ChIP-seq), which maps the genome-wide localization patterns of transcription factors and epigenetic marks, is among the most widely used methods in molecular biology. Practical Guide to ChIP-seq Data Analysis will guide readers through the steps of ChIP-seq analysis: from quality control, through peak calling, to downstream analyses. It will help experimental biologists to design their ChIP-seq experiments with the analysis in mind, and to perform the basic analysis steps themselves. It also aims to support bioinformaticians to understand how the data is generated, what the sources of biases are, and which methods are appropriate for different analyses.