While one may not find ancient studies that substantiate the pomegranate's curative and preventive qualities, the exalted status of this fruit goes back as far as the history of agriculture itself. Allusions to the pomegranate are readily found in the oldest cultures of the Indus Valley, ancient China, and classical Greece, as well as in the Old Testament.
To modern scientists, the biochemistry of the pomegranate is as equally fascinating as its storied place in literature and religion. Providing an unprecedented compilation of scientific information, Pomegranates: Ancient Roots to Modern Medicine offers an exploration of the biochemistry, health effects, and cultivation of the pomegranate that is as authoritative as it is unparalleled. Featuring the contributions of a multidisciplinary and international team of prominent researchers, it presents the latest findings on the potential human health benefits of this exceptionally polyphenol-rich fruit.
As the research indicates, the physiological effects of pomegranate juice constituents are remarkable in their preventive potential against two of the major chronic diseases of aging - heart disease and cancer.
Many of the pioneering researchers responsible for initiating our newfound fascination with pomegranates discuss its biochemistry, detailing the location and action of the phytochemicals found in the fruit's flesh, peels and seeds. They present evidence of the pomegranate's impact on heart disease, including its ability to enhance nitric oxide production in endothelial cells. They also reveal the significant antiproliferative and proapoptotic effects attributed to the pomegranate in battling several different types of cancer cells, as well as its ability to retard tumor growth in animals.
Recognizing that the pomegranate is only as valuable as it is available, the editors include a substantial section on commercialization and another on plant growth and improvement. These additions make this text as uniquely essential for botanists and agriculturists as it is for nutritionists, cancer researchers, natural product chemists, botanical supplement producers and consumers, and pharmacognosists seeking to evaluate both the pomegranate's legacy and future as a powerful natural healing agent.
Table of Contents
Pomegranate Phytochemicals; Navindra P. Seeram, Yanjun Zhang, Jess D. Reed, Christian G. Krueger, and Jakob Vaya
Antioxidative Properties of Pomegranate: In Vitro Studies; Mira Rosenblat and Michael Aviram
Bioavailability of Pomegranate Polyphenols; Francisco A. Tomás-Barberán, Navindra P. Seeram, and Juan Carlos Espín
Cardiovascular I: Protection against Cardiovascular Diseases; Bianca Fuhrman and Michael Aviram
Cardiovascular II: Protection Against Stroke; Marva I. Sweeney-Nixon
Cancer I: Anticancer Potential of Pomegranate; Shishir Shishodia, Lynn Adams, Indra D. Bhatt, and Bharat B. Aggarwal
Cancer II: Molecular Mechanisms of Chemoprevention of Cancer by Pomegranate; Deeba Syed, Arshi Malik, Naghma Hadi, Caroline Schmitt, Farrukh Afaq, and Hasan Mukhtar
Cancer III: Pomegranate and Prostate Cancer Chemoprevention; John T. Leppert and Allan J. Pantuck
Estrogen Studies I: Estrogenic Compounds and Lack of Estrogenic Effects In Vitro; Diane M. Harris, Emily Besselink, and Navindra P. Seeram
Estrogen Studies II: Absence of Significant Estrogenic Effects in the Postmenopausal Population; Michelle P. Warren, Eliza Ng, Russalind H. Ramos, and Sari Halpert
Antimicrobial Activities of Pomegranate; G.K. Jayaprakasha, P.S. Negi, and B.S. Jena
Commercialization of Pomegranates: Fresh Fruit, Beverages, and Botanical Extracts; Navindra P. Seeram, Yanjun Zhang, and David Heber
Plant Growth and Improvement
Pomegranates: A Botanical Perspective; David W. Still
Postharvest Biology and Technology of Pomegranates; Adel A. Kader
Summary; Risa N. Schulman
"As popularity and research regarding pomegranate preparations continue to increase, both functional foods and dietary supplements, this book will no doubt become one of the primary references on this compelling functional fruit."
– Keith R. Martin, Director, Nutrition Research, POM Wonderful, LLC, in HerbalGram, Aug/ Sept/ Oct 2007, No. 75