Polymorphism in Pharmaceutical Solids

2nd Edition

Harry G. Brittain

CRC Press
Published July 27, 2009
Reference - 656 Pages - 200 B/W Illustrations
ISBN 9781420073218 - CAT# H7321
Series: Drugs and the Pharmaceutical Sciences

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Summary

Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins.

Topics include:

  • Computational methodologies
  • High-throughput screening methods
  • Pharmaceutical cocrystals
  • Thermally-induced and solution-mediated phase transformations
  • Amorphous solids
  • Crystallography preparation and characterization
  • The amorphous state

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