2nd Edition

Polymorphism in Pharmaceutical Solids

Edited By Harry G. Brittain Copyright 2009
    652 Pages 200 B/W Illustrations
    by CRC Press

    Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins.

    Topics include:

    • Computational methodologies
    • High-throughput screening methods
    • Pharmaceutical cocrystals
    • Thermally-induced and solution-mediated phase transformations
    • Amorphous solids
    • Crystallography preparation and characterization
    • The amorphous state

    THERMODYNAMIC AND THEORETICAL ISSUES
    Theory and Principles of Polymorphic Systems
    , Harry G. Brittain
    Application of the Phase Rule to the Characterization of Polymorphic and Solvatomorphic Systems, Harry G. Brittain
    Computational Methodologies: Toward Crystal Structure and Polymorph Prediction, Sarah (Sally) L. Price

    PREPARATIVE METHODS FOR POLYMORPHS AND SOLVATOMORPHS
    Classical Methods of Preparation of Polymorphs and Alternative Solid Forms,
    Peter W. Cains
    Approaches to High-Throughput Physical Form Screening and Discovery, Alastair J. Florence

    STRUCTURAL PROPERTIES OF POLYMORPHS AND SOLVATOMORPHS
    Structural Aspects of Polymorphism,
    Harry G. Brittain, Stephen R. Byrn, and Eunhee Lee
    Structural Aspects of Solvatomorphic Systems, Harry G. Brittain, Kenneth R. Morris, and Stephan X. M. Boerrigter
    Pharmaceutical Co-crystals: A New Opportunity in Pharmaceutical Science for a Long-Known but Little-Studied Class of Compounds, Kapildev K. Arora and Michael J. Zaworotko

    CHARACTERIZATION METHODS FOR POLYMORPHS AND SOLVATOMORPHS
    Thermoanalytical and Crystallographic Methods,
    Sisir Bhattacharya, Harry G. Brittain, and Raj Suryanarayanan
    Vibrational Spectroscopy, Harry G. Brittain
    Solid-State Nuclear Magnetic Resonance Spectroscopy, Patrick A. Tishmack
    Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate, Harry G. Brittain, David J. R. Grant, and Paul B. Myrdal

    INTERCONVERSION OF POLYMORPHS AND SOLVATOMORPHS
    Solid-State Phase Transformations,
    Harry G. Brittain
    Effects of Pharmaceutical Processing on the Solid Form of Drug and Excipient Materials, Peter L. D. Wildfong

    SPECIAL TOPICS RELATED TO POLYMORPHISM AND SOLVATOMORPHISM
    Structural Aspects of Molecular Dissymmetry,
    Harry G. Brittain
    Amorphous Solids, Lynne S. Taylor and Sheri L. Shamblin
    Index

    Biography

    Brittain, Harry G.