Polycystic Kidney Disease

1st Edition

Jinghua Hu, Yong Yu

CRC Press
Published November 14, 2019
Reference - 346 Pages - 20 Color & 30 B/W Illustrations
ISBN 9781138603899 - CAT# K388346
Series: Methods in Signal Transduction Series

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Summary

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies.

Key Features

  • Explores the role of cilia in polycystic kidney disease
  • Focuses on myriad state-of-the-art methods and techniques
  • Reviews specific mutations integral to this autosomal genetic disease
  • Includes discussions of model systems

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