Physics of Thermal Therapy: Fundamentals and Clinical Applications

Eduardo Moros

December 5, 2012 by CRC Press
Reference - 375 Pages - 15 Color & 281 B/W Illustrations
ISBN 9781439848906 - CAT# K12209
Series: Imaging in Medical Diagnosis and Therapy


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  • Overviews heat transfer, thermal dose models, practical invasive and non-invasive thermometry, and numerical modeling for simulation and treatment planning
  • Discusses the latest advances in non-invasive thermometry, MRI-guided high-intensity focused ultrasound, and enhanced drug delivery using liposomes and hyperthermia
  • Includes chapters on cutting-edge topics such as magnetic nanoparticles for cancer therapy, thermal therapy applications of microbubbles, and thermochemical ablation
  • Covers the fundamental physics of thermal therapy, including chapters on bio-heat transfer, thermal dose, thermometry, electromagnetic and acoustic energy sources, and numerical modeling
  • Overviews of clinical systems, covering internally and externally applied electromagnetic and acoustic energy sources
  • Describes the physical aspects of an emerging thermal therapy technology, covering both conventional as well as emerging imaging technologies and tools for image-guided therapies


The field of thermal therapy has been growing tenaciously in the last few decades. The application of heat to living tissues, from mild hyperthermia to high-temperature thermal ablation, has produced a host of well-documented genetic, cellular, and physiological responses that are being researched intensely for medical applications, particularly for treatment of solid cancerous tumors using image guidance. The controlled application of thermal energy to living tissues has proven a great challenge, requiring expertise from multiple disciplines, thereby leading to the development of many sophisticated pre-clinical and clinical devices and treatment techniques. Physics of Thermal Therapy: Fundamentals and Clinical Applications captures the breadth and depth of this highly multidisciplinary field.

Focusing on applications in cancer treatment, this book covers basic principles, practical aspects, and clinical applications of thermal therapy. An overview of the fundamentals shows how use of controlled heat in medicine and biology involves electromagnetics, acoustics, thermodynamics, heat transfer, and imaging sciences. The book discusses challenges in the use of thermal energy on living tissues and explores the genetic, cellular, and physiological responses that can be employed in the fight against cancer from the physics and engineering perspectives. It also highlights recent advances, including the treatment of solid tumors using image-guided thermal therapy, microbubbles, nanoparticles, and other cutting-edge techniques.

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