Pharmaceutical Biocatalysis: Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases

1st Edition

Peter Grunwald

Jenny Stanford Publishing
July 9, 2019 Forthcoming
Reference - 774 Pages - 34 Color & 74 B/W Illustrations
ISBN 9789814800617 - CAT# K425243
Series: Pan Stanford Series on Biocatalysis

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Summary

The relationship between biocatalysis and the different areas of pharmaceutics is discussed in volumes 4 to 6 of Pan Stanford Series on Biocatalysis.

Volume 4 provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, the main regulatory authorities, rare diseases and orphan drugs, the costs of drug development and therapies, and the use of enzymes in downstream processing of pharmaceuticals. Examples of therapeutic enzyme inhibitors discussed are carbonic anhydrase inhibitors together with their multiple drug interactions, carboxylesterase inhibitors and human diseases, and the application of (multifunctional) inhibitors of monoamine oxidase and cholinesterase for the treatment of Alzheimer’s disease. The text also covers engineered proteins and bioactive peptides as therapeutic formulations and fibrinolytic enzymes for thrombolytic therapy. Different chapters discuss the enzymes employed for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology.

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