Ravi Durvasula, Scott Matthews
June 30, 2019 Forthcoming
Reference - 520 Pages - 15 Color Illustrations
ISBN 9781498760614 - CAT# K28691
For Instructors Request Inspection Copy
This book presents an overview of paratransgenesis, an innovative approach to the control of infectious disease. In paratransgenic interventions, an arthropod vector’s bacterial symbiont is transformed to express molecules directed against a target pathogen. The vector is inoculated with the transformed bacterium via a bait formulation. The bacteria replicate in the vector and export antipathogen molecules, resulting in interruption of disease transmission. Paratransgenesis offers a sustainable, environmentally friendly alternative to vector eradication using pesticides, which is limited by environmental toxicity, cost, and development of vector resistance.
Global Health Challenges in the 21st century. A History of Paratransgenesis. Paratransgenic Laboratory Techniques. Paratransgenesis and vector borne disease in humans and animals. Paratransgenesis and aquatic disease. Paratransgenesis and agricultural pests. The structure of paratransgenic interventions. A risk assessment framework for paratransgenesis. The future of Paratransgenesis.