Despite the progress being made by researchers, Alzheimer’s disease, along with other age-related neurodegenerative disorders, continues to exact a tremendous toll on our society. However, we are beginning to see a relationship that ties degenerative disorders to oxidative stress and lifestyle, suggesting the possibility for prevention and intervention through changes of individual habits, especially with regard to diet.
Oxidative Stress and Age-Related Neurodegeneration brings together expert researchers involved with recent developments across a variety of fields. In looking at causation, prevention, and therapy, they offer contributions addressing these questions: What similarities and differences exist between normal aging and disease-related neurodegeneration in terms of susceptibility to and effects of oxidative stress? How can oxidative stress or its effects be attenuated? Do antioxidants prevent or slow the progress of the disease? Is there any role for natural micronutrients in the attenuation of oxidative stress and prevention of age-related neurodegeneration?
Some chapters look at the various ways research is getting to the core of neurodegenerative disease, including the use of proteomics, comparisons to related diseases, and examinations at the cellular and molecular levels. Other chapters focus on specific antioxidants and nutrients cited as being impactful, such as those found in Gingko biloba, green tea, blueberries, and grape seed extract.
Researchers in academia, industry, and clinical medicine, as well as students and scholars will find use for this timely collection, either as an introduction to our current understanding of neurodegeneration or as a reference for further research. Clinicians will also benefit, as this book explains the basis for many of the latest approaches to prevention and therapy.
Table of Contents
Proteomics Identification of Oxidatively Modified Proteins in the Alzheimer’s Disease Brain and Models Thereof: Insights into Potential Mechanisms of Neurodegeneration; D. A. Butterfield, H. F. Poon, R. Sultana
Direct Evaluation of Alzheimer’s Disease-Specific Oxidative Stress with Multiphoton Microscopy; M. Garcia-Alloza, S.A. Dodwell, B.J. Bacskai
Ginkgo biloba Extract and Alzheimer’s Disease: Is the Neuroprotection Explained Merely by the Antioxidant Action? Y. Christen
Mitochondrial Nutrients: Reducing Mitochondrial Decay to Delay or Treat Cognitive Dysfunction, Alzheimer’s Disease, and Parkinson’s Disease; J. Liu, B. N. Ames
Reactive Oxygen and Nitrogen Species: Weapons of NeuronalDestruction; J R. Mazzulli, S. Lind, H. Ischiropoulos
Amyloid ß and Tau in Alzheimer’s Disease: What is the Neuropathology Trying to Tell Us? R.J. Castellani, A. Nunomura, H. Lee, X. Zhu, G. Perry, M.A. Smith
Antioxidant Therapies in the Prevention and Treatment of Alzheimer Disease; PI. Moreira, X. Zhu, A. Nunomura, M.A. Smith, G. Perry
F2-Isoprostanes as Biomarkers of Late Onset Alzheimer’s Disease; T. J. Montine, J.F. Quinn, J.A. Kaye, J. D. Morrow
Aspirin and Alzheimer’s Disease Protection; S. E. Nilsson S. Berg
The Disposition of Lipid-Derived Carbonyls in Alzheimer’s Disease; M. J. Picklo, Sr;
Methionine Sulfoxide Reductase System: Possible Roles in Protection against Neurodegenerative Diseases; J. Moskovitz, A.I. Bush
Nutritional Antioxidant Enrichment and Improved Cognitive Function in Canines; E. Head, C.W. Cotman
Green Tea and Resveratrol as Protective Agents against Neurotoxins; S. Bastianetto, H. Ying-Shan, Q. Rémi
Oxidative Stress and AßPP Processing; T. Massimo, T. Elena
Apple Phenolics and Alzheimer’s Disease; H.J. Heo, D. Kim, C.Y. Lee
Effects of Nicotine in Models of Alzheimer’s Disease; B. Zhao
The Essentiality of Iron Chelation in Neuroprotection: A Potential Role of Green Tea Catechins; S.A. Mandel, T. Amit, H. Zheng, O. Weinreb, M.B.H. Youdim
Ginkgo biloba Extract Egb761 Extends Life Span and Attenuates H2O2 Levels in a Caenorhabditis elegans Model of Alzheimer’s Disease; J.V. Smith, Y. Luo
Cysteine Proteases as ß-Secretases for Aß Production in the Major Regulated Secretory Pathway of Neurons: Implications for Therapeutic Strategies in Alzheimer’s Disease; V. Hook, T. Toneff, G. Hook, T. Reisine
The Molecular Mechanism of the Neuroprotective Action of Antioxidants Compared with the Anti-Parkinson Drug, Rasagiline; O. Weinreb, T. Amit, S.A. Mandel, M.B.H. Youdim
Temporal Primacy of Oxidative Stress in the Pathological Cascade of Alzheimer Disease; A. Nunomura, K. Tabata, S. Chiba, M.A. Smith, G. Perry
Age-Related Neuronal and Behavioral Deficits are Improved by Polyphenol-Rich Blueberry Supplementation; F.C. Lau, B. Shukitt-Hale, J.A. Joseph
Amyloid-ß Peptide, a Therapeutic Target for Alzheimer’s Disease? Y. Luo, P. Butko
Nutrition, Brain Aging, and Alzheimer’s Disease; Y. Zhang, R. Li
Interaction between Dietary and Genetic Deficiencies in the Modulation of Homocysteine Elimination; F. Tchantchou, T.B. Shea
Nutriproteomics Approach to Understanding Dementia-Relevant Brain Protein Changes in Response to Grape Seed Extract, a Dietary Antioxidant; H. Kim, S. Eliuk, J. Deshane, S. Barnes, S. Meleth