Epidemiological studies have estimated that approximately 35 percent of cancers are potentially avoidable by nutritional modification. These modifications include strategies such as caloric restriction and limitation of specific macro-nutrient groups. However, recent research indicates that what you eat may well be just as important as what you shun when it comes to avoiding cancer, especially colon, breast, and prostate cancers, which have become epidemic in the Western hemisphere.
Nutrition and Cancer Prevention brings together the top experts in nutritive health who present significant evidence that specific dietary micronutrients have the potential to play a role in resisting cancer, modulating its development, or reducing tumor metastasis. As a way of introduction, the book updates the descriptive epidemiology of the major cancers of the Western world, and then discusses the likely mechanisms of action that occur when certain essential nutrients become diet staples. The text moves on to explore the scientific evidence, looking at the various properties of each class of micronutrient, chapter by chapter.
These classes include vitamins; minerals, particularly calcium and selenium; phytosterols and polyphenols, which are found in soy and green tea; isothiocyanates found in broccoli, kale, and other cruciferous vegetables; and specialized dietary lipids, including omega-3 fatty acids, linoleic acid, and sphingolipids. The book also dedicates chapters to the roles that obesity and excessive alcohol consumption play in cancer development.
“…we can hope to utilize nutritional interventions to slow the progression of tumor development in the intraepithelial hyperplasia phase before tumor size becomes large enough for diagnosis and probability of metastasis increases. Opportunity exists to stretch this prevention phase so that symptom-free life of the future patient with cancer is prolonged.”
--from Chapter 2, How Dietary Components Protect from Cancer, Diane M. Harris and Vay Liang W. Go
Partial List of Bioactive Food Components with Cancer-Preventive
Properties That Are Detailed in This Volume and Their Primary Food
Table of Contents
Epidemiology of Breast, Prostate, and Colon Cancers-- Maddalena Barba, Barbara Fuhrman, Barbara Teter, and Paola Muti.
How Dietary Components Protect from Cancer --Diane M. Harris and Vay Liang W. Go.
Dietary Components That Protect from Cancer: Vitamins
Vitamin A, ß-Carotene, and Cancer -- Joseph L. Napoli.
Anticarcinogenic Activity of Natural and Synthetic Carotenoids -- Hoyoku Nishino, Michiaki Murakoshi, Xiao Yang Mou, Saeri Wada, Mitsuharu Masuda, Yasuhito Ohsaka, Yoshiko Satomi, and Kenji Jinno.
Vitamin D and the Risk of Cancer -- Sujatha Sundaram and David A. Gewirtz
Vitamin E Analogs as Anticancer Agents -- Jiri Neuzil, Xiu-Fang Wang, Yan Zhao, and Kun Wu
Vitamin C Blocks Carcinogenic Tumor Formation -- Ki Won Lee, Hyong Joo Lee, and Chang Yong Lee
Folic Acid, Folates, and Cancer -- John J. McGuire
Dietary Components That Protect from Cancer: Minerals
Calcium and Chemoprevention of Colon Cancer -- Subhas Chakrabarty, Ph.D.
Relationship of Selenium Intake to Cancer -- P.D. Whanger
Dietary Components That Protect from Cancer: Phytosterols
Phytosterols: Sources and Metabolism -- Elke A. Trautwein and Guus S.M.J.E. Duchateau
Phytosterols: Bioactivity on Cancer -- Peter G. Bradford and Atif B. Awad
Dietary Components That Protect from Cancer: Polyphenols
Classification, Dietary Sources, Absorption, Bioavailability, and Metabolism of Flavonoids -- Jeremy P.E. Spencer
Isoflavones, Soybean Phytoestrogens, and Cancer -- Fazlul H. Sarkar and Yiwei Li
Implications of Flavonoids as a Sex Hormone Source -- David Jenkins and Roxanne LaBelle
Flavonoids as Inhibitors of Tumor Metastasis -- Jin-Rong Zhou
Catechins and Inhibitory Activity against Carcinogenesis -- Jen-Kun Lin
Cancer Chemoprotective Activity of Stilbenes: Resveratrol -- Catherine A. O’Brian, Jubilee R. Stewart, and Feng Chu
Flaxseed and Lignans: Effects on Breast Cancer -- Krista A. Power and Lilian U. Thompson
Anthocyanins and Cancer Prevention --Colin D. Kay and Bruce J. Holub
Dietary Components That Protect from Cancer: Isothiocyanates
Isothiocyanates and Cancer Prevention -- Marilyn E. Morris and Urvi Telang
Dietary Components That Protect from Cancer: Saponins Anticancer Activity of Ginseng and Soy Saponins -- David G. Popovich and David D. Kitts
Dietary Components That Protect Cancer: Specialized Lipids
Omega-3 Fatty Acids and Cancer Prevention -- Bandaru S. Reddy
Conjugated Linoleic Acid and Cancer-- Yongsoon Park
Sphingolipids as Chemopreventive Agents -- Eva M. Schmelz
Dietary Cancer Risk Factors
Obesity as a Cancer Risk Factor: Epidemiology -- Yang Mao, Sai Yi Pan, and Anne-Marie Ugnat
Obesity as a Cancer Risk Factor: Potential Mechanisms of Action -- Henry J. Thompson, Weiqin Jiang, and Zongjian Zhu
Alcohol and Cancer: Cellular Mechanisms of Action -- Xiang-Dong Wang and Hiroko Inoue-Fruehauf
“the contributors of leading experts in the field who examine the role of nutrition in helping to forestall the onset of cancer. The authors here dissect the material in classic fashion, always looking for the elements of scientific evidence that elevate their premises and hypotheses. This treatise centers itself around the fact that certain classes of micronutrients appear to be able to strengthen the cell structure, allowing the body to then “resist” the birth of a cancer (these micronutrients include vitamins; minerals; phytosterols; polyphenols; isothiocyanates; and specialized dietary lipids).Furthermore, the authors are careful to note just what food sources hold these beneficial nutrients, in addition to documenting each micronutrient’s role in limiting inflammation and impeding tumor growth. … Recommended to all oncologists and researchers who are seeking to explore the link between cancer and nutrition. Noted for the depth of information presented which serves to document the correlation between certain classes of micronutrients and the body’s ability to fight the onset of cancer. Also recommended to Health Science libraries for its rich and long-term reference value.”
— John Aiello, in Electric Review