Current research has given us a more complete understanding of how the chemicals in foods and herbs interact with natural and synthetic drugs. In some cases a single food or supplement can profoundly increase or decrease the toxicity and/or efficacy of a single drug. Although it is standard practice to examine the effects of food consumption on the absorption and pharmacokinetics of new drugs, the issue has become greater than "should this medicine be taken with or without food."
Nutrient-Drug Interactions focuses on food, herbals, and their chemical constituents as contributors to human health through control of metabolism, primarily as they relate to chronic disease development and treatment. The book's organization highlights the ailment being treated or prevented and the targets of therapy. Each chapter provides a comprehensive examination of the macronutrient, micronutrient, and phytochemical impact on drug action and includes advice on modification or supplementation in those cases where diet is a factor. The chapters focus on the molecular mechanism by which a food or chemical is thought to modify disease process and drug behavior. The book describes the roles of genetic variation and polymorphism in determining nutrient/drug responses, how they might be "profiled" to identify those likely to demonstrate specific interactions, and who would benefit from adjuvant or complementary therapies.
The book explores how what is consumed affects response, whether on a population or individual level, to the pharmacologic agents that are the mainstay of chronic disease treatment/prevention around the world.
Table of Contents
Diabetes, Obesity and Metabolic Syndrome, A.J. Scheen
Hypolipidemic Therapy: Drugs, Diet, and Interactive Effects, A. Loktionov
Phytochemicals, Xenobiotic Metabolism, and Carcinogenesis, J.B. Kirkland
Nutrient and Phytochemical Modulation of Cancer Treatment, K.A. Meckling
Role of Nutritional Antioxidants in the Prevention and Treatment of Neurodegenerative Disorders, E. Esposito
Nutrients and Herbals in the Pharmacotherapy of Unipolar/Major Depression, M. Chronowic
Supplements and Anesthesiology, A.D. Kaye, A. Baluch, and J.M. Hoover
Nutrient and Drug Responsive Polymorphic Genes as Nutrigenomic Tools for Prevention of Cardiovascular Disease and Cancer, K. Wood and M. Bakovic
Nutrigenomics and Pharmacogenomics of Human Cancer: On the Road from Nutrigenetics and Pharmacogenetics, A. Loktionov
"…an extremely helpful framework by which the effects and interactions of drugs and nutrients can be understood."
-Doody's Review Service