Nonclinical Drug Administration: Formulations, Routes and Regimens for Solving Drug Delivery Problems in Animal Model Systems

Shayne C. Gad, Charles B. Spainhour

August 15, 2017 by CRC Press
Reference - 406 Pages - 11 B/W Illustrations
ISBN 9781466502536 - CAT# K14441


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  • Includes principles of dosing route selection and the calculation of the maximum dose of drug that can be administered by route and model species
  • Presents techniques on how to calculate exposure for safety testing requirements, as well as tricks to achieving such systemic exposure
  • Discusses how to achieve highly selective administration of a drug to a specific therapeutic target
  • Provides a compendium of useable nonclinical formulation vehicles and excipients; maximum tolerable levels by route, species, and study duration; and how to develop nonclinical formulations that work


The concept of the perfect medicine as a molecule that goes with high selectivity to the therapeutic target site, does what it needs to do, and is subsequently cleared from the body is especially relevant now. Much of the current costs and post-market safety concerns arise from the inability to achieve adequate concentrations and selectivity in the due course of actually delivering the active drug. Providing an integrated approach, this book presents ways of achieving the desired adequate and selective delivery using the currently available technology in three tool sets: route, regimen, and formulation.


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