Allergic contact dermatitis from nickel is a continuing and increasing health problem. Nickel dermatitis may occur in sensitized individuals following contact with nickel-containing items such as jewelry, zippers, buttons, and other objects; by nickel leaching from implants and prostheses; and following occupational exposures. Although the most common of the health effects associated with exposure to nickel, the skin penetration of nickel and its compounds is poorly understood.
Nickel and the Skin: Absorption, Immunology, Epidemiology, and Metallurgy gives an extensive, updated review of major topics and new topics, and covers material progress in the field of nickel hypersensitivity. Its content complements the mandate of NiPERA, the Nickel Producers Environmental Research Association, which is to promote the health and safety of those exposed to nickel or nickel containing products in the workplace and general environment.
Many books on the toxicology of metals discuss nickel and its alloys in general terms. This one provides you with in-depth information on the causes, diagnosis, prognosis, and prevention, all in one source. Nickel and the Skin: Absorption, Immunology, Epidemiology, and Metallurgy provides a guide to the evaluation and treatment of what has become the most common cause of allergic contact dermatitis.
Table of Contents
Aspects of Nickel Allergy: Etiology, Epidemiology, Immune Reactions, Prevention, and Therapy, J.J. Hostynek
Nickel Allergic Hypersensitivity: Prevalence and Incidence by Country, Gender, Age, and Occupation, J.J. Hostynek, K.E. Reagan, and H.I. Maibach
Oxidative Properties of the Skin: A Determinant for Nickel Diffusion, J.J. Hostynek, K.E. Reagan, and H.I. Maibach
Release of Nickel Ion From the Metal and Its Alloys as Cause of Nickel Allergy, J.J. Hostynek, K.E. Reagan, and H.I. Maibach
Skin Absorption of nickel and methods to Quantify Penetration, J.J. Hostynek, K.E. Reagan, and H.I. Maibach
Diagnostic Testing for Nickel Allergic Hypersensitivity: Patch Testing vs. Lymphocyte Transformation Test, J.J. Hostynek, K.E. Reagan, and H.I. Maibach
Orally Induced Tolerance to Nickel: The Role of Oral Exposure (Orthodontic Devices) in Preventing Sensitization, J.J. Hostynek, K.E. Reagan, and H.I. Maibach
Biochemical Aspects of Nickel Hypersensitivity: Factors Determining Allergenic Action, B. Santucci, E. Camera, and M. Picardo
Nickel Metal Alloys, G.N. Flint and C.P. Cutler
Appendix A: Glossary