Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics-as well as potential new therapeutic approaches!
This comprehensive volume addresses the latest treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies.
Presents the most up-to-date information available on the genetics, epidemiology, pathology, pharmacology, and pulmonology of asthma.
Written by more than 20 leading international experts, New and Exploratory Therapeutic Agents for Asthma
explores asthma both as incidence of dysfunctional airway smooth muscle and as a disorder of the immune system
examines the role of monoclonal antibodies in allergy and asthma
describes functions and pharmacokinetic profiles of bronchodilator 2 agonists, anticholinergics, and inhaled glucocorticosteroids
investigates the controversy of different types of asthma
illustrates the connections between clinical symptoms and the immunopathology of eosinophilic inflammation
assesses prospects for the development of a successful oral anti-inflammatory therapy, an immunomodulator that lowers antigen-specific IgE, an anticytokine compound, and an agent that safely combines bronchospasmolytic and anti-inflammatory properties
reviews the impact of the recent introduction of antileukotriene agents, clinical findings with PAF antagonists, and selective antimuscarinics
evaluates the relationship between improvements in laboratory results and clinical effectiveness
Containing over 2000 bibliographic citations and a concise introduction for each chapter, New and Exploratory Therapeutic Agents for Asthma is indispensable for pulmonologists, pediatricians, physiologists, immunologists, allergists, pharmaceutical industry scientists, primary care physicians, and medical school students in these disciplines.
Table of Contents
Epidemiology of Asthma
Stephen T. Holgate and A. N. Banik
Pathophysiology of Asthma
Peter J. Sterk
Pathology of Asthma
Muscarinic Receptor Subtypes and Anticholinergic Therapy
Allison D. Fryer, Richard W. Costello, and David B. Jacoby
Long-Acting 2-Agonist Drugs
Richard Beasley, Julian Crane, and Carl Burgess
Inhaled Glucocorticoids, Established and New
Joseph D. Spahn and Stanley J. Szefler
Platelet-Activating Factor Antagonists in Bronchial Asthma
Devendra K. Agrawal and Robert G. Townley
Tachykinin Receptor Antagonists
Guy F. Joos and Charles Advenier
Therapeutic Potential of Phosphodiesterase Type 4 Inhibitors in the Treatment of Asthma
Bernadette Hughes and Gerry Higgs
Anthony P. Sampson and Zuzana Diamant
The Anti-IgE Treatment Strategy for Asthma
John V. Fahy
Activity of T-Cell Subsets in Allergic Asthma
André Boonstra and Huub F. J. Savelkoul
New Targets for Future Asthma Therapy
Peter J. Barnes
Current Practice and Future Trends in Clinical Trials in Asthma
Johan C. Kips and Romain A. Pauwels
…well-written and thoroughly referenced….provides up-to-date, easy-to-read, and high-quality coverage of new developments in asthma pharmacotherapies….highly recommend[ed].