Linking advances in physics, engineering, materials science, chemistry, and biotechnology for the utilization of nanoparticles in drug delivery, this guide describes methods for the manufacture of nanoparticles including milling, homogenization, and supercritical fluid technologyoffers technologies for stabilizing nanoparticlespresents drug delivery applications of nanoparticles by parenteral and oral routesdescribes the latest advances in the application of nanoparticles for drug delivery to the brain and eyesummarizes the recent developments in the use of nanoparticles for gene deliverydetails the characterization of nanoparticles at the material and physicochemical levelprovides nanoparticles technologies for the delivery of conventional and contemporary drugshighlights the efficacy and potential toxicity of nanoparticles
Nanoparticles, products of nanotechnology, are of increasing interest to the pharmaceutical community. They can increase drug solubility, enhance bioavailability, allow tissue targeting, offer decreased side-effects, and improve therapeutic efficacy. Presenting the most pertinent and practical issues in the manufacturing and biological application of nanoparticles, this source presents state-of-the-art scientific contributions by seasoned authorities in the field.
Table of Contents
PART I: Technologies for Nanoparticle Manufacturing. Fundamentals of Drug Nanoparticles. Manufacturing of Nanoparticles by Milling and Homogenization Techniques. Supercritical Fluid Technology for Particle Engineering. Polymer or Protein Stabilized Nanoparticles from Emulsions. PART II: Nanoparticle Characterization and Properties. Physical Characterization of Nanoparticles. Nanoparticle Interface: An Important Determinant in Nanoparticle-Mediated Drug/Gene Delivery. Toxicological Characterization of Engineered Nanoparticles. PART III: Drug Delivery Applications of Nanoparticle. Injectable Nanoparticles for Efficient Drug Delivery. Polymeric Nanoparticles for Oral Drug Delivery. Brain Delivery by Nanoparticles. Nanoparticles for Ocular Drug Delivery. DNA Nanoparticle Gene Delivery Systems. PART IV: Clinical, Ethical, and Regulatory Issues. Nanotechnology and Nanoparticles: Clinical, Ethical, and Regulatory Issues