Myelodysplastic Syndromes: Pathobiology and Clinical Management

2nd Edition

David Steensma

CRC Press
Published December 12, 2008
Reference - 536 Pages - 45 Color & 19 B/W Illustrations
ISBN 9781420074390 - CAT# H7439
Series: Basic and Clinical Oncology


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Written by a team of leading authorities in pathogenesis, diagnostic techniques, and clinical management strategies in myelodysplastic syndrome (MDS), this text provides a concise, easy-to-follow review of the advances in the science, classification, diagnosis, and management of the condition.

An ideal source for hematologists, oncologists, and cancer researchers, this Second Edition features:

  • a new eight-page color insert
  • 200 color and black-and-white illustrations
  • reworked content organized into three sections: MDS epidemiology and biology; diagnosis, classification, and prognosis; and MDS therapy
  • thoroughly updated chapters reflecting a shift from the topical focus as dictated by the evolution of the field

New topics in Myelodysplastic Syndrome include:

  • del(5q) and 5q-syndrome, CMML, and MDS-MPD overlap syndrome
  • the reborn DNA methyltransferase inhibiting nucleoside analogs
  • the diagnosis of chronic myelomonocytic leukemia and other MDS cases with myeloproliferative features
  • the role of mitochondria and the potential importance of iron overload in MDS
  • global genomics approaches, such as cDNA expression arrays, array-based comparative genomic hybridization, and single nucleotide polymorphism array
  • the role of abnormal mitochondrial ferritin accumulation and other mitochondrial metabolic anomalies in MD
  • other disease-associated alterations, such as abnormalities of B lymphocyte populations in MD
  • three recently approved drugs: azacitidine, lenalidomide, and decitabine

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