This unique volume provides an integrated overview of the subject of monovalent cations, specifically aimed at students and researchers. It is divided into two parts: the first deals with the processes by which monovalent cations are transported across biological membranes; the second deals with the processes that are affected by changes in intracellular cations. Each chapter describes in simple biochemical terms the interaction between one or more monovalent cations and a particular biological system of importance to current understanding of body function in health and disease. This useful publication is invaluable to students and researchers in biochemistry, physiology, neurology, pharmacology, anesthesiology, cardio-pulmonology, hematology, laboratory medicine, endocrinology, gastroenterology, internal medicine, psychiatry, urology, biomedical physics and medical nutrition.
Table of Contents
Ion Selectivity of Pentameric Protein Channels: Backbone Carbonyl Ligands as Cation Binding Ligands and Side Chain Hydroxyls as "Ambidextrous" Ligands for Cations or Anions in Viral Capsids. Models of Voltage- and Transmitter-Activated Membrane Channels Based on Their Amino Acid Sequences. Electrogenic Ion Transport. Electroneutral Transport and Exchange. The H+-ATPase from Fungal Plasma Membranes. Setting of Membrane Potential. Generation of Action Potentials by Sodium and Potassium Channels. Cosubstrate Driven Organic Solute Transport. Monovalent Cations and Control of Mitochondrial Respiration. The pH of Intracellular Compartments. The Role of Monovalent Cations in the Determination of Cell Volume. Monovalent Ion Fluxes and Growth Stimulation: Early Activation of the Na+/H+ Antiport and the Na+/K+ Pump in Fibroblast Mitogenesis. Cation-DNA Interactions: NMR and Theoretical Studies of Ion Distributions and Dynamics. Lithium in Medicine. Ammonium and Organic Cations. Index.