April 26, 2019 Forthcoming
Textbook - 500 Pages - 512 Color Illustrations
ISBN 9780815345237 - CAT# Y169377
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Molecular and Cellular Biology of Viruses is a new undergraduate textbook focusing on how viruses interact with host cells at a molecular level. All the major classes of viruses are included, with separate chapters for the replication and expression strategies of the different classes, and integrated chapters for mechanisms that are common across the classes: attachment, entry, and assembly.
The mechanistic chapters are followed by a discussion of the overall effect of viral infection on the host cell, both for infections that kill the host cell and for infections that don’t. Coverage of the immune system is limited to the interplay between host defenses (both innate and adaptive) and viruses. Also included are anti-viral therapies and the medical applications of viruses, such as their use in gene therapy. The book finishes with a chapter on viral evolution: where viruses came from and how they became what they are today.
Coverage of molecular mechanisms is rigorous but not overwhelming, making the text suitable for students to read before class. Each chapter ends with conceptual questions and there are separate experimental design and data analysis questions.
1. The Fundamentals of Molecular and Cellular Virology
2. The Virus Replication Cycle
3. Attachment, Penetration, and Uncoating
4. Gene Expression and Genome Replication in Model Bacteriophages
5. Gene Expression and Genome Replication in Positive Strand RNA Viruses
6. Gene Expression and Genome Replication in the Negative Strand RNA Viruses
7. Gene Expression and Genome Replication in the Double-Stranded RNA Viruses
8. Gene Expression and Genome Replication in the Double-Stranded RNA Viruses
9. Gene Expression and Genome Replication in the Single-Stranded DNA Viruses
10. Gene Expression and Genome Replication in the Retroviruses and Hepadnaviruses
11. Assembly, Maturation & Release
12. Virus-Host Interactions During Lytic Growth
13. Persistent Viral Infections
14. Innate Host Defenses and Viral Strategies that Evade Them
15. Adaptive Host Defenses and Viral Strategies that Evade Them
16. Medical Applications of Molecular and Cellular Virology
17. Viral Diversity, Origins, and Evolution
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