To gain a complete overview of what is presently known about molecular carcinogenesis would prove to be a very daunting task for those not already steeped in this complex subject. Fortunately, David Warshawsky and Joseph Landolph Jr., both highly respected for their own contributions to the field, know exactly whom to call upon to fulfill the need for a definitive summary.
Molecular Carcinogenesis and the Molecular Biology of Human Cancer provides a technical, as well as historical, overview of research covering the science of cancer. This volume explores molecular information specific to chemical, viral, and radiation carcinogenesis, explains the working of cellular oncogenes and tumor suppressor genes, and also introduces readers to the latest genomic and proteomic approaches.
The first part of the book offers basic information; the second part deals strictly with cancer in humans. It commences with discussions on induction and exposure, then reviews complex mixtures of chemical carcinogens, and provides several chapters on tumors, organized by specific organs.
This section also covers chemoprevention of chemical carcinogenesis, exposure assessment, and biomarkers, as well as the role of risk assessment, before offering a discussion on prevention that includes the history and particulars of carcinogen regulations.
Featuring leading researchers writing about their areas of expertise, this book provides a succinct yet detailed reference that meets the needs of professional researchers, clinicians, and environmental regulators, as well as attorneys practicing law in the area of toxic torts. Its progressive structure allows it to also serve as a primary text or resource for students in medicine and cancer research.
Table of Contents
Carcinogens and Mutagens: David Warshawsky
Whole Animal Carcinogenicity Bioassays: Joseph R. Landolph, Jr., Weiling Xue, and David Warshawsky
Molecular Mechanisms of Action of Selected Organic Carcinogens: Weiling Xue and David Warshawsky
Binding of Carcinogens to DNA and Covalent Adducts and DNA Damage- PAH, Aromatic Amines, Nitro-aromatic Compounds, and Halogenated Compounds: Jeffrey Ross
Cellular Oncogenes and Carcinogenesis: Helmut Zarbl
Tumor Suppressor Genes: Bernard E. Weissman
Hepatitis B, Hepatitis C, and Hepatocellular Carcinoma: Jing-hsiung Ou
Oncongenesis in Transgenic and Knockout Mice: Laura Erker and Anthony Wynshaw-Boris
Chemically Induced Morphological and Neoplastic Transformation in C3H/10T1/2 Cl 8 Mouse Embryo Cells: Joseph R. Landolph Jr.
Radiation Carcinogenesis: Colin K. Hill and Donna M. Williams-Hill
DNA Microarrays and Computational Analysis of DNA Microarray Data in Cancer Research: Mario Medvedovic and Jonathan S. Wiest
Application of Proteomics in Basic Biological Sciences and Cancer: Christoph Borchers, Ting Chen, and Nouri Neamati
Overview of Human Cancer Induction and Human Exposure to Carcinogens: David Warshawsky and Joseph R. Landolph Jr.
Complex Mixtures of Chemical Carcinogens: Principles of Action and Human Cancer: Stephen Nesnow
Lung Cancer: Jay W. Tichelaar and George D. Leikauf
Breast Cancer: Sue C. Heffelfinger
Cancer of the Prostate- Mechanisms of Molecular Carcinogenesis: Daniel Djakiew
Skin Cancer: Epidemiology, Clinical Manifestations, and Genetic and Molecular Aspects: Zalfa A. Abdel-Malek, Ana Luisa Kadekaro, Michelle A. Pipitone, and Diya F. Mutasim
Cell and Molecular Biology of Cancer of the Brain: Ole Didrik Laerum
Thyroid Cancer: Molecular Biology and Clinical Aspects: Johan R. Lillehaug, Øystein Fluge, and Jan Erik Varhaug
Chemoprevention of Chemical Carcinogenesis and Human Cancer: Mark A. Morse and Gary D. Stoner
Carcinogen Biomarkers and Exposure Assessment: Glenn Talaska
Risk Assessment for Chemical Carcinogens: Andrew G. Salmon
Chapter 24 Prevention and Regulation Approaches to Carcinogens: Eula Bingham and Jon Reid