Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process.
This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.
Table of Contents
Changes in the Extracellular Matrix During Transformation and Differentiation (James Varani, Ph.D. and Subhas Chakrabarty, Ph.D.). Interactions of Tumor Cells with Basement Membranes (Victor Terranova, D.M.D., Ph.D.). Endothelial Cell Function and Metastasis (Michael R. Buchanan, Ph.D. and Maria Bertomeau, M.D.). Passage Across the Vascular Wall by Malignant Cells in Metastasis Formation (Peter De Bruyn, M.D.). Entry of Cancer Cells Into the Vasculature (Kurt Hellmann, M.D.). Interactions Between Circulating Cancer Cells and Host Leukocytes (Dorothy Glaves, Ph.D.). Platelets and Cancer Metastasis (Kenneth V. Honn, Ph.D., Irma M. Grossi, Ph.D., Josepf Timar, Ph.D., Hemi Chopra, Ph.D., and John Taylor, Ph.D.). The Thrombotic Consequences of Malignancy (Mohan Chelladurai, Ph.D.). The Biomechanics of Cancer Cell Traffic, Arrest, and Intravascular Destruction (Leonard Weiss, M.D.). The Role of Integrin Receptors in Tumor Cell Adhesion to the Microvasculature (Randall H. Kramer, Ph.D., Judy Ennenstein, Ph.D., Daniel M. Ramos, D.D.S., Mai P. Vu, B.Sc., and Yao Fen Cheng, M.Sc.). Interactions Between Cancer Cells and the Endothelium (Robert Auerbach, Ph.D.). Selective Involvement of a Specific Sinusoidal Domain in Hepatic Metastasis (Emilio Barberá-Guillem, M.D. and Fernando Vidal-Vanaclocha, M.D.). The Morphology of Cancer Cell Arrest and Extravasation (John Crissman, M.D., Robert Cerra, Ph.D., and Fuzlul Sarkar, Ph.D.). Fatty Acid Metabolism and Cancer Cell-Endothelial Cell Interactions (Michael R. Buchanan, Ph.D., Maria Bertomeau, M.D., and Thomas A. Haas, Ph.D.). The Influence of Endothelial Injury and Inflammatory Processes on Metastasis (F. William Orr, M.D.). The Role of Vascularization in Tumor Metastasis (Marsha Moses, Ph.D.). The Microcirculation of Tumors (Hans-Inge Peterson, M.D.).