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Methods in Signal Transduction Series


About the Series

The concept of signal transduction is now long established as a central tenet of biological sciences. Since the inception of the field close to fifty years ago, the number and variety of signal transduction pathways, cascades and networks have steadily increased and now constitute what is often regarded as a bewildering array of mechanisms by which cells sense and respond to extracellular and intracellular environmental stimuli. It is not an exaggeration to state that virtually every cell function is dependent on the detection, amplification and integration of these signals. Moreover, there is increasing appreciation that in a many disease states, aspects of signal transduction are critically perturbed.

Our knowledge of how information is conveyed and processed through these cellular molecular circuits and biochemical switches has increased enormously in scope and complexity since this series was initiated fifteen years ago. Such advances would not have been possible without the supplementation of older technologies, drawn chiefly from cell and molecular biology, biochemistry, physiology and pharmacology, with newer methods that make use of sophisticated genetic approaches as well as structural biology, imaging, bioinformatics and systems biology analysis.

The overall theme of this series continues to be the presentation of the wealth of up to date research methods applied to the many facets of signal transduction. Each volume is assembled by one or more editors who are pre-eminent in their specialty. In turn, the guiding principle for editors is to recruit chapter authors who will describe procedures and protocols with which they are intimately familiar in a reader-friendly format. The intent is to assure that each volume will be of maximum practical value to a broad audience, including students and researchers just entering an area, as well as seasoned investigators.

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Signaling Through Cell Adhesion Molecules

Signaling Through Cell Adhesion Molecules

1st Edition

Jun-Lin Guan
May 20, 1999

The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing , and...

G ProteinsTechniques of Analysis

G ProteinsTechniques of Analysis

1st Edition

David R. Manning
May 19, 1999

Incorporating a bench-top format, G Proteins: Techniques of Analysis covers essential methods - with a commitment to those techniques of proven and current utility.G Proteins: Techniques of Analysis includes expression and functional analysis of G proteins; evaluation of covalent modifications and...

Lipid Second Messengers

Lipid Second Messengers

1st Edition

Ronald P. Rubin, Suzanne Laychock
November 17, 1998

Lipid Second Messengers provides detailed methodology for analysis of various lipid signaling pathways. Authoritative contributors explain the factors that regulate lipid second messenger production by agonist-activated enzymes and examine their products. Topics discussed include procedures used to...

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