The concept of signal transduction is now long established as a central tenet of biological sciences. Since the inception of the field close to fifty years ago, the number and variety of signal transduction pathways, cascades and networks have steadily increased and now constitute what is often regarded as a bewildering array of mechanisms by which cells sense and respond to extracellular and intracellular environmental stimuli. It is not an exaggeration to state that virtually every cell function is dependent on the detection, amplification and integration of these signals. Moreover, there is increasing appreciation that in a many disease states, aspects of signal transduction are critically perturbed.
Our knowledge of how information is conveyed and processed through these cellular molecular circuits and biochemical switches has increased enormously in scope and complexity since this series was initiated fifteen years ago. Such advances would not have been possible without the supplementation of older technologies, drawn chiefly from cell and molecular biology, biochemistry, physiology and pharmacology, with newer methods that make use of sophisticated genetic approaches as well as structural biology, imaging, bioinformatics and systems biology analysis.
The overall theme of this series continues to be the presentation of the wealth of up to date research methods applied to the many facets of signal transduction. Each volume is assembled by one or more editors who are pre-eminent in their specialty. In turn, the guiding principle for editors is to recruit chapter authors who will describe procedures and protocols with which they are intimately familiar in a reader-friendly format. The intent is to assure that each volume will be of maximum practical value to a broad audience, including students and researchers just entering an area, as well as seasoned investigators.
Polycystic Kidney Disease
Signal Transduction and Smooth Muscle
Autophagy and Signaling
Calcium Entry Channels in Non-Excitable Cells
Gap Junction Channels and Hemichannels
Jinghua Hu, Yong Yu
November 07, 2019
This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channel in primary cilia of...
Mohamed Trebak, Scott Earley
September 11, 2018
All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of...
September 14, 2017
Autophagy and Signaling is an up-to-date overview of the many signaling pathways regulating autophagy in response to different cellular needs. Discussion includes the status and future directions of autophagy signaling research with respect to different aspects of health and disease. These include...
Michael X. Zhu
September 12, 2017
The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic...
Eric J. Murphy, Eric Murphy, Thad Rosenberger, Thad A. Rosenberger
September 12, 2017
As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade’s worth of advances in...
Juliusz Ashot Kozak, James W. Putney, Jr.
June 08, 2017
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium...
Jonathan Soboloff, Dietmar J. Kappes
March 09, 2017
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume...
Donglin Bai, Juan C. Sáez
August 18, 2016
Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and...
May 12, 2015
Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new...
Gregory W. Konat
June 20, 2008
The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of...
Steven J. Fliesler, Oleg G. Kisselev
December 26, 2007
In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents...
Malcolm Whitman, Amy Sater
August 15, 2006
Developmental biologists have been driven to investigate growth factor signaling in embryos in order to understand the regulatory mechanisms underlying a given developmental process. Thus, it is critical to explore the technical methods and experimental designs for growth factor signaling in...