In the past two decades, pain research has become one of the most rapidly growing areas of neuroscience activity. Methods in Pain Research brings together in a single volume a survey of the methods that can be used to study a reaction or 'sensory report' in humans that can only be inferred by indirect means in animal or tissues studies. It presents source material, useful advice, and guidance to specific details as well as examples of current usage.
With each topic presented by one or more of the leading experts in the field, it examines the major modern techniques used in studying pain, including gene linkage, brain imaging methods, the use of transgenic rodent models, painful sensory neuropathy models, and more. The material also covers conventional methods of pain study, such as anatomical and electophysiological techniques. Methods in Pain Research provides up-to-date methodology and a guide to the strategies of experimental design.
Table of Contents
The Idiosyncratic Problems Associated with Pain Research, Lawrence Kruger
Assessing Nociception in Murine Subjects, Jeffrey S. Mogil, Sonya G. Wilson, and You Wan
Techniques for Mutagenesis of the Murine Opioid System In Vivo, Michael D. Hayward and
Animal Models of Pain, Gary Bennett
Methods in Visceral Pain Research, Timothy J. Ness and Gerald F. Gebhart
The Cytokine Challenge: Methods for the Detection of Central Cytokines in Rodent Models of Persistent Pain, Sarah M. Sweitzer, Janice L. Arruda, and Joyce A. DeLeo
Extracellular Sampling Techniques, Igor Spigelman, Neubert Y. Matsuka, and N.T. Maidment
Electrophysiological Recording Techniques in Pain Research, Igor Spigelman, Michael S. Gold, and Alan R. Light
Membrane Properties: Ion Channels, Michael S. Gold
Anatomical Methods in Pain Research, Susan Carlton and A. Todd
Quantitative Morphology in Relation to Long-Term Pain States: Estimates of Neuron Numbers, Richard E. Coggeshall
Functional Brain Imaging in Humans: Methodology and Issues, Karen Davis
Methods for Imaging Human Brain Pathophysiology of Chronic Pain, Vania A. Apkarian, Ogor D. Grachev, Beth R. Krauss, and Nikolaus M. Szeverenyi
Methods for Induction and Assessment of Pain in Humans with Clinical and Pharmacological Examples, Thomas Graven-Nielson, Marta Segerdahl, Peter Svensson, and Lars Arendt-Nielson
"The author's objective is to address methods of pain research from different angles, particularly considering the protocols developed in anesthesia and neuroscience laboratories across the world. Those objectives are clearly met…In a well-written approach, the authors address different points of pain research…The scope is broad but the text, to-the-point. The author's expertise is expressed in the conciseness of the text, the graphic quality, the illustrations, and the explanations for the procedures…This is an important book for neuroscience libraries and laboratories involved in the study of pain. 4 stars!"
- Celso Agner, MSc, MD, Albany Medical Center, New York, USA in Doody's Notes