Environmental endocrine disruptors have been at the heart of discussions about chemicals and their effects on fertility, but the focus has been on organic compounds and the role of metals has been largely overlooked - until now. Taking an organ-system-based approach, Metals, Fertility, and Reproductive Toxicity examines the effects of metals found in the everyday environment on fertility rates in humans and animal populations.
This volume summarizes and evaluates the literature in the area of metal effects on fertility and reproduction in humans, laboratory animals, and wildlife. International experts have contributed chapters that explore how the ovary, testes, uterine system, and neuroendocrine system, among others, respond to metal exposure. Reviewing both current knowledge and cutting edge data, the chapters focus on either a particular metal or a particular population.
A massive amount of data on this subject has been generated, summarized, and reviewed over the years. While there are many books available on metals toxicity and on reproductive toxicity, no current book explores both in the same volume. Culling information from throughout the literature, Metals, Fertility, and Reproductive Toxicity supplies an in-depth look at the role of metals in endocrine disruption and the spectrum of mechanisms involving metals that can influence reproduction.
Table of Contents
Introduction, M.S. Golub
REPRODUCTIVE TOXICITY OF MERCURY, CADMIUM, AND ARSENIC, M.S. Golub
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF ORGANOTIN COMPOUNDS, M. Ema and A. Hirose
Effects on Aquatic Organisms
Effects on Experimental Animals
ADVERSE EFFECTS OF ALUMINUM, URANIUM, AND VANADIUM ON REPRODUCTION AND INTRAUTERINE DEVELOPMENT IN MAMMALS, J.L. Domingo
INTRAUTERINE AND REPRODUCTIVE TOXICITY OF NUTRITIONALLY ESSENTIAL METALS, M.S. Golub
Studies in Humans
Studies in Animals
LEAD EXPOSURE AND ITS EFFECTS ON THE REPRODUCTIVE SYSTEM, R.Z. Sokol, M.D., M.P.H.
Sources and Routes of Exposure
Absorption and Metabolism
Physiology of Reproduction
Effects of Lead on Male Reproduction
Effects of Lead on Female Reproduction
IMPACT OF METALS ON OVARIAN FUNCTION, P.B. Hoyer, Ph.D.
Sites of Disruption of Ovarian Function
Consequences of Ovarian Toxicity
Metals: Ovarian Effects
Summary and Future Directions
EPIDEMIOLOGICAL AND OCCUPATIONAL STUDIES OF METALS IN MALE REPRODUCTIVE TOXICITY, W.A. Robbins, Ph.D.
Methodological Considerations in Studies
of Human Male Reproduction and Metals
Specific Metals and Human Male Reproduction
USE OF METAL REPRODUCTIVE TOXICITY DATA IN SELECTING ECOLOGICAL TOXICITY VALUES FOR SMALL MAMMALS INHABITING HAZARDOUS WASTE SITES, M.J. Anderson, J.T. Yamamoto, and H. Waites
Toxicity Reference Values
Example of TRV Derivation: Lead
Predicting Potential Ecological Risks of Lead