1st Edition

Metals, Fertility, and Reproductive Toxicity

Edited By Mari S. Golub Copyright 2006
    274 Pages 2 B/W Illustrations
    by CRC Press

    Environmental endocrine disruptors have been at the heart of discussions about chemicals and their effects on fertility, but the focus has been on organic compounds and the role of metals has been largely overlooked - until now. Taking an organ-system-based approach, Metals, Fertility, and Reproductive Toxicity examines the effects of metals found in the everyday environment on fertility rates in humans and animal populations.

    This volume summarizes and evaluates the literature in the area of metal effects on fertility and reproduction in humans, laboratory animals, and wildlife. International experts have contributed chapters that explore how the ovary, testes, uterine system, and neuroendocrine system, among others, respond to metal exposure. Reviewing both current knowledge and cutting edge data, the chapters focus on either a particular metal or a particular population.

    A massive amount of data on this subject has been generated, summarized, and reviewed over the years. While there are many books available on metals toxicity and on reproductive toxicity, no current book explores both in the same volume. Culling information from throughout the literature, Metals, Fertility, and Reproductive Toxicity supplies an in-depth look at the role of metals in endocrine disruption and the spectrum of mechanisms involving metals that can influence reproduction.

    Introduction, M.S. Golub

    REPRODUCTIVE TOXICITY OF MERCURY, CADMIUM, AND ARSENIC, M.S. Golub
    Introduction
    Mercury
    Cadmium
    Arsenic
    References

    REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF ORGANOTIN COMPOUNDS, M. Ema and A. Hirose
    Introduction
    Effects on Aquatic Organisms
    Effects on Experimental Animals
    Conclusions
    References

    ADVERSE EFFECTS OF ALUMINUM, URANIUM, AND VANADIUM ON REPRODUCTION AND INTRAUTERINE DEVELOPMENT IN MAMMALS, J.L. Domingo
    Aluminum
    Uramium
    Vanadium
    Conclusions
    References

    INTRAUTERINE AND REPRODUCTIVE TOXICITY OF NUTRITIONALLY ESSENTIAL METALS, M.S. Golub
    Introduction
    Studies in Humans
    Studies in Animals
    References

    LEAD EXPOSURE AND ITS EFFECTS ON THE REPRODUCTIVE SYSTEM, R.Z. Sokol, M.D., M.P.H.
    Sources and Routes of Exposure
    Absorption and Metabolism
    Physiology of Reproduction
    Effects of Lead on Male Reproduction
    Effects of Lead on Female Reproduction
    Summary
    References

    IMPACT OF METALS ON OVARIAN FUNCTION, P.B. Hoyer, Ph.D.
    Introduction
    Ovarian Physiology
    Sites of Disruption of Ovarian Function
    Consequences of Ovarian Toxicity
    Metals: Ovarian Effects
    Summary and Future Directions
    References

    EPIDEMIOLOGICAL AND OCCUPATIONAL STUDIES OF METALS IN MALE REPRODUCTIVE TOXICITY, W.A. Robbins, Ph.D.
    Introduction
    Methodological Considerations in Studies
    of Human Male Reproduction and Metals
    Specific Metals and Human Male Reproduction
    Summary
    References

    USE OF METAL REPRODUCTIVE TOXICITY DATA IN SELECTING ECOLOGICAL TOXICITY VALUES FOR SMALL MAMMALS INHABITING HAZARDOUS WASTE SITES, M.J. Anderson, J.T. Yamamoto, and H. Waites
    Introduction
    Toxicity Reference Values
    Example of TRV Derivation: Lead
    Predicting Potential Ecological Risks of Lead
    Conclusions
    References

    Index

    Biography

    Mari S. Golub