This book brings together work from leading researchers to present the most recent advances in research on metallothionein. This protein interests toxicologists because it is thought that metallothionein protects against metal toxicity and possibly against oxidative stress. It is of interest to pharmacologists because modification of metallothionein levels might have a role in cancer chemotherapy. Nutritionists have an interest in this protein because it appears to be a major storage protein for zinc. Biochemists and molecular biologists will be interested in the mechanisms of regulation of this protein because it is extremely inducible.
Table of Contents
Cd-hem Method and Its Application (Satomi Onosaka and Keiichi Tanaka). A Cd-Saturation Assay for Cu-Containing Metallothionein (Karl H. Summer, Rudiger Bartsch, and Dominik Klein). The Development and Utilization of Immunological Probes for Detection/Quantitation of Metallothionein (Justine S. Garvey). Chemistry of Mammalian Metallothionein (Jeremias H.R. Kagi and Milan Vasak). Regulation of Human and Yeast Metallothionein Gene Transcription by Heavy Metal Ions (Petra Skroch, Carla Buchman, and Michael Karin). Function and Regulation of Yeast Cu-Metallothionein (Dean Hamer, Valeria Culotta, Peter Furst, Rebecca Hackett, Tsao Hsu, Stella Hsu, and Ravi Kumbadur). Native and Engineered Metallothioneins (P.C. Huang, Chris Cody, Mary Cismowski, Mark Chernaik, In-Koo Rhee, and L.Y. Lin). Molecular Biology of the Chicken Metallothionein Gene (Glen K. Andrews and Lawrence P. Fernando). Species Differences in Metallothionein Regulation: A Comparison of the Induction of Isometallothioneins in Rats and Mice (Lois D. Lehmann-McKeeman, William C. Kershaw, and Curtis D. Klaassen). Metallothionein and Sulfur Metabolism in Newborn Rat Liver (M. George Cherian). Induction of Metallothionein by Emotional Stress (Koji Arizono, Akiko Tanabe, Minehiro Moriyama, and Toshihiko Ariyoshi). Hormonal Induction of Metallothionein Synthesis: Its Effect on Zinc Kinetics in the Rat (Michael A. Dunn). The Metallothionein Gene Family in Candida glabrata (R.K. Mehra and D.R. Winge). Effect of Preinduction of Metallothionein Synthesis on Toxicity of Free Radical Generating Compounds in Mouse (Akira Naganuma, Masaiko Satoh, and Nobumasa Imura). Proximal Tubule Cell Injury (B.A. Fowler, R.E. Gandley, M. Akkerman, M.M. Lipsky, and M. Smith). Assessment of Nutritional Status by Immunoassay of Metallothionein (Ian Bremner, Nancy A. Noble, Aileen Robertston, and Anne M. Wood). Possible Role of Metallothioneins in Growth, Differentiation, and Carcinogenesis of Mouse Skin (Mika Karasawa, Hiroki Hashiba, Chiharu Rohyama, Noriko Nishimura, and Toshio Kuroki). Involvement of Metallothionein in the Prevention of Gastric Mucosal Lesions (Kazutake Tsujikawa, Takumi Imai, Tsutomu Mimura, Noriko Otaki, and Masami Kimura). The Possible Role of Metallothionein in Atherogenesis (Katsuyuki Nakajima, Masakazu Adachi, Noriko Otaki, Masami Kimura, Takwshi Tani, Takehiro Igawa, Umeko Kawaharada, and Keiji Suzuki). Possible Application of Metallothionein in Cancer Therapy (Nobumasa Imura, Masahiko Satoh, and Akira Naganuma). Chronic Cadmium Exposure and Metallothionein (Zahir A. Shaikh). Meeting Synopsis and Future Directions for Metallothionein Research (M. Webb). Index.