Cancer research is becoming multidisciplinary. The complex structural and therapeutic problems require synergistic approaches employing an assortment of biochemical manipulations, chromatographic or electrophoretic separations, sequencing strategies, and … more and more mass spectrometry.
Mass Spectrometry in Cancer Research provides a broad examination of current strategies and techniques and their application to the study of:
(i) occupational and environmental carcinogens;
(ii) antineoplastic and chemopreventive agents;
(iii) pertinent proteins, lipids, nucleic acids and glycoconjugates. Also included are a chapter on instrumentation and methodologies for biologists and physicians and a brief review of the relevant concepts of cancer biology and medicine for mass spectrometrists.
This book is intended for: mass spectrometrists in research or those providing core services; researchers in biological, medical, pharmaceutical or environmental sciences; physicians in academic medicine; and academic/industrial research managers.
The Essentials
Functions and Types of Instrument Components
Measures of Performance
Information from Mass Spectra and Scope of Applications
INSTRUMENTATION AND TECHNIQUES OF MASS SPECTROMETRY
Ion Sources
Mass Analyzers
Ion Current Detectors
Mass Spectrometry-Mass Spectrometry (MS/MS)
Identification and Quantification
Resources
RELEVANT CONCEPTS OF CANCER MEDICINE AND BIOLOGY
Classification and Epidemiology
Cellular Proliferation and Communication
Genetic Abnormalities in Cancer
Tumor Immunology
Diagnosis and Treatment
Some Pertinent Experimental Methods
METABOLISM AND BIOMARKERS OF CARCINOGENS
Classification, Mechanisms of Action and Biomarkers
Occupational Carcinogens
Environmental Carcinogens
DNA Damage by Radiation and Oxidation
ANTINEOPLASTIC AND CHEMOPREVENTIVE AGENTS
Cytotoxic Therapy
Endocrine Therapy
Targeted Drug Delivery and Therapy
Nutritional and Chemical Prevention
STRATEGIES, TECHNIQUES AND APPLICATIONS IN CANCER BIOCHEMISTRY AND BIOLOGY
Proteins and Peptides
Lipids
Oligonucleotides and Nucleic Acids
Carbohydrates and Glycoconjugates
REFERENCES
INDEX
Biography
John Roboz
"This is a unique and very useful tool for biologists interested in mass spectrometry. Written with biologists in mind, it provides a good background for novices in the field and illustrates the potential of mass spectrometry in molecular biology and oncology. …it serves to connect these fields for a wide range of scientists. 4 stars!"
- Victor V. Levenson, MD, PhD, Northwestern University Medical School, Doody's Notes
"…an invaluable resource for mass spectrometrists. The text provides a myriad of experimental applications and strategies for the MS analyses of molecules that are central to the development and prevention of cancer. All mass spectrometrists who are interested in doing cancer research should procure a copy."
- M. Paul Chiarellia, Loyola University, in Journal of the American Society for Mass Spectrometry, Volume 14, Issue 1
