1st Edition

Lithium in Neuropsychiatry The Comprehensive Guide

    552 Pages 1 B/W Illustrations
    by CRC Press

    552 Pages 1 B/W Illustrations
    by CRC Press

    The definitive textbook on the use of lithium in the treatment of mental disorders, this comprehensive work provides an up-to-date analysis of lithium, including:

    • History
    • Clinical applications, including its use for mania, bipolar and schizophrenic disorders
    • Use in special populations, for example in children, the elderly and people with medical conditions
    • The effect on the body and behavior, including neurological, gastrointestinal, cardiovascular and dermatological effects, as well as those relating to the kidneys and thyroid
    • Basic findings in pharmacology, chemistry, transport in the body, pharmacokinetics, signal transduction pathways, immune function, gene regulation.
    • Practical issues, such as guidelines for safe use, discontinuation issues, compliance, intoxication, and economics.

    Edited by top experts from the International Group for the Study of Lithium Treated Patients (IGSLi), Lithium in Neuropsychiatry: A Comprehensive Guide is a unique and vital resource for psychiatrists, psychopharmacologists, psychotherapists and neuroscientists.

    Foreword

    K.R Jamison (Baltimore, USA)

    Preface

    M Bauer, P Grof & B Muller-Oerlinghausen

     

    SECTION A – Introduction, History

    1. Lithium: a fascinating element in neuropsychiatry.

    P.C. Whybrow (Los Angeles, USA)

    2. History of lithium’s discovery

    M. Schou (Aarhus, Denmark) & P. Grof (Ottawa, Canada)

    3. History of Lithium’s use in North America

    S.Gershon (Pittsburgh, USA)

    4. Different views on the use of Lithium across continents

    F.Goodwin (Washington, USA)

    5. Lithium in international and national guidelines

    B. Muller-Oerlinghausen & M Bauer (Berlin, Germany)

    6. Lithium treatment: user’s perspective

    Mary Lou Selo (New York, USA)

     

    SECTION B. CLINICAL APPLICATIONS

    B.1 – Mood and related disorders

    7. Use of lithium in acute mania

    R.Llicht (Aarhus, Denmark)

    8. Use of lithium in maintenance treatment of bipolar disorder

    J Geddes & G Goodwin (Oxford, UK)

    9. Effectiveness of Lithium in naturalistic settings

    M.Maj (Naples, Italy)

    10. Use of lithium in maintenance treatment of unipolar affective disorder

    JM Davis (Chicago, USA)

    11. Efficacy in the treatment of acute unipolar and bipolar depression

    M Bauer & T Bschor (Berlin, Germany)

    12. Use of lithium in schizoaffective and schizophrenic disorders

    C.Baethge (Koln, Germany) & C Simhandl (Neunkirchen, Austria)

    13. Lithium in rapid cycling bipolar disorder

    J.Calabrese (Cleveland, USA) & Michael Bauer (Berlin, Germany)

    14. Excellent responders, subtyping, predictors of response

    P.Grof (Ottawa, Canada)

    15. Suicide-preventive and mortality reducing activity

    B.Müller-Oerlinghausen (Berlin, Germany), B.Ahrens &

    W.Felber (Dresden, Germany)

    16. Treatment of lithium non-responders

    W. Greil & N Kleindienst (Zurich, Switzerland)

    B.2 Special populations and applications in medicine

    17. Children, adolescents and off-spring

    A.Duffy (Ottawa, Canada)

    18. Lithium in geriatric populations

    L.Gyulai & R. Young (Philadelphia, USA)

    19. Women and lithium treatment (contraception, pregnancy & teratogenety)

    B. Schmitz (Berlin, Germany)

    20. Applications of lithium in medical conditions (hyperthyroidism, anti-viral activity, & cluster headache)

    T. Bschor (Berlin, Germany), U. Lewitzka, & M. Adli (Dresden, Germany)

     

    B.3 Effects on Body Systems

    21. Renal effects of lithium

    M.Schou (Aarhus, Denmark) & D Kampf (Berlin, Germany)

    22. Effects of lithium on the thyroid and endocrine glands

    JH Lazarus (Cardiff, UK)

    23. Neurological effects of lithium (incl. EEG)

    U.Hegerl (Munich, Germany)

    24. Effects of lithium on the cardiovascular and gastrointestinal systems, and on metabolic activity (body weight)

    J.Rybakowski, A Suwalska (Poznan, Poland) & I Paclt (Prague, Czech Republic)

    25. Dermatological effects of lithium

    A Pfennig (Berlin, Germany) & D Deshauer (Ottawa, Canada)

    C. Pharmacology and Mechanisms

    26. Chemistry and biochemistry of the lithium ion

    N.Birch (UK)

    27. Pharmakokinetics

    M.Alda (Halifax, Canada)

    28. Interaction of lithium with neurotransmitter systems (5-HT and others)

    G.Juckel (Berlin, Germany)

    29. Signal transduction pathways

    D. Van Calker (Freiburg, Germany)

    30. Effects of lithium on gene regulation

    L.T Young (Toronto, Canada)

    31. Neurotrophic and neuroprotective effects of lithium

    H.Manji (Bethesda, USA)

    32. Potential use in neurodegenerative disorders

    De-Maw Chuang (Bethesda, USA) & J Priller (Berlin, Germany)

    33. Effects of lithium on immune function

    VS Gallicchio (Lexington, USA)

    34. Results from brain imaging studies

    J.Soares (San Antonio, USA)

    35. Genetics of excellent Lithium responder

    M.Alda, P.Zvolshy & P.Grof

    36. Effects on behaviour and cognition (animals and healthy humans)

    R.Belmaker (Beer Sheva, Israel)

    D. Practical Issues

    37. Guidelines for its safe use (indications and contraindications, pre-treatment investigations, dosing, investigations during long-term treatment, prevention and precaution of intoxication and other adverse events- e.g. body weight increase combination with other medications)

    A.Berghöfer (Berlin, Germany), P Grof & B. Müller-Oerlinghausen

    38. Latency and discontinuation issues (rebound phenomena, loss of efficacy after discontinuation)

    R.Baldessarini (Boston, USA) L. Tondo & C.Baethge

    39. Compliance and adherence during long-term treatment

    P.Vestergaard (Aarhus, Denmark) & K.Thau (Vienna, Austria)

    40. Lithium intoxication: signs and treatment

    Intensive Care Physician & Psychiatrist T.B.A

    41. Lithium Information Center of the Madison Institute of Medicine

    JW Jefferson & JH Griest (Madison, USA)

    42. Economics of lithium prophylaxis

    A.Berghöfer (Berlin, Germany)

    Appendices

    Biography

    Michael Bauer, Paul Grof, Bruno Muller-Oerlinghausen

    "This is a superb, comprehensive, and essential book on the medical and psychiatric uses of lithium."

    "This is an excellent and long needed book on the use of lithium. No resident should be allowed to finish training without knowing the information contained in this book. It should be required reading for all psychiatrists who treat seriously mentally ill patients."
    Michael J. Schrift, Doody's Reviews, February 2007

    "This well written book provides an authoritative and comprehensive synopsis of lithium use in various neuropsychiatric disorders. Written primarily for clinicians, this book should also appeal to interested researchers, psychopharmacologists, and experts in mood disorders. The book’s major strength is the depth of information and the breadth of subject material discussed. In hardcover, the text is attractive in layout and is free of production errors. Each chapter is followed by an exhaustive list of references. Given the amount of material covered and the size of the book, it is reasonably priced." - Verinder Sharma, Canadian Journal of Psychiatry 2006