Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects

1st Edition

Mulchand S. Patel, Lester Packer

CRC Press
Published March 17, 2008
Reference - 556 Pages - 145 B/W Illustrations
ISBN 9781420045376 - CAT# 45377
Series: Oxidative Stress and Disease

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Features

  • Compiles expert contributions to provide researchers with a state-of-the-science benchmark
  • Reviews early discoveries and the basic structure, biosynthesis, and characterization of lipoic acid
  • Defines the role of lipoic acid in energy production and antioxidant activity
  • Explains the pharmacodynamics and metabolism of lipoic acid
  • Describes clinical applications with supporting evidence from animal models
  • Summary

    The recognition of oxidative stress as a major factor in health, aging, and disease has led to a surge in research aimed at uncovering effective countermeasures in the form of antioxidants. Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. Mounting data regarding its potential health benefits demands an authoritative, single-source reference to codify current knowledge and guide future research.  

    A state-of-the-science compilation, Lipoic Acid follows the history of this potent coenzyme and the latest discoveries regarding the chemistry, biological action, and significance in energy production, antioxidant activity, and health. The book is divided into three sections:

    ·         Section I: Discovery and Molecular Structure reviews the early studies leading to the discovery of alpha-lipoic acid and explains the molecular structure, biosynthesis, and the characterization of lipoic acid and its chemical derivatives.

    ·         Section II: Metabolic Aspects describes in detail the human pharmacokinetics of alpha-lipoic acid including the lipoic acid-derived dehydrogenase complexes and their roles in energy metabolism. It also explains antioxidant activity and redox modulation and how lipoic acid induces Phase II detoxification enzymes through activation of Nrf2-dependent gene expression.

    ·         Section III Clinical Aspects discusses enzyme deficiency disorders and the effects of lipoic acid on insulin. It defines lipoic acid influence on signaling pathways and AMP-activated kinase, and considers the therapeutic implications for treatment of metabolic syndromes and the improvement of mitochondrial function by lipoic acid supplementation.

    Contributions from leading international researchers make Lipoic Acid the most comprehensive, up-to-date account of the impact of this potentially key molecule in diminishing the damaging effects of aging and disease.

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