Lipid Second Messengers provides detailed methodology for analysis of various lipid signaling pathways. Authoritative contributors explain the factors that regulate lipid second messenger production by agonist-activated enzymes and examine their products. Topics discussed include procedures used to measure lipid-derived mediators such as lysophospholipids, arachidonic acid, eicosanoids, anandamide, and ceramides, and the enzymes responsible for generating these messengers, such as phospholipases, prostaglandin endoperoxide synthases, and sphingomyelinase.
Table of Contents
Phospholipase D, L. Freysz and J.N. Kanfer
Analyzing the Sphingomyelin Cycle: Protocols for Measuring Sphingomyelinase, Sphingomyelin, and Ceramide, H. Hayter and Y.A. Hannun
Expression of the Human Prostaglandin Endoperoxide H Synthases: Measurement of Cyclooxygenase Activity and Inhibition by Non-Steroidal Antiinflammatory Drugs, D. DeWitt
Phospholipid Growth Factors: Identification and Mechanisms of Action, G.J. Tigyi, K. Liliom, D.J. Fischer, Z. Guo
Leukotriene and Lipoxin Biosynthesis, B.D.Levy, K. Gronert, C. Clish, and C.N. Serhan
Purification and High-Resolution Analysis of Anandamide and Other Fatty Acylethanolamides, A. Giuffrida and D. Piomelli
...a valuable account of a developing technology that may, at long last, place liposomes on the map of sucessful drug delivery systems."
- J. Controlled Release