Light and Electron Microscopic Neuropathology of Slow Virus Disorders provides extensive coverage of the neurobiology and neuropathology of slow, unconventional virus disorders also known as prion diseases. The book features an outstanding group of contributers, including Nobel Laureate Dr. D. Carleton Gajdusek and his co-workers. Studies range from the classical to the modern and are based on light microscopy, electron microscopy, and immunohistochemistry. Specific topics covered include spongiform encephalopathies and the hypothesis of infectious polypeptides, structure of the agent, neuropathology of kuru, Creutzfeldt-Jakob disease, Gerstmann-Str�sler-Scheinker diseases, scrapie, bovine spongiform encephalopathy, and chronic wasting disease. Many chapters are based on findings from over 15,000 unpublished micrographs from cases and experimental models. The book also features an extensive list of references ranging from classic 19th century studies to studies through mid-1992.
Light and Electron Microscopic Neuropathology of Slow Virus Disorders will be an excellent reference for neurologists, neuropathologists, virologists, neurobiologists, and other scientists interested in these virus disorders.
Table of Contents
1. Transmissible Amyloidosis of the Brain 2. Pathogenesis of Unconventional Slow Virus Infections 3. The Molecular Biology of Transmissible Spongiform Encephalopathy - Infectious Cerebral - Amyloidosis 4. Models of Slow Viruses 5. An Overview of Neuropathology of the Slow Unconventional Virus Infections 6. Natural Scrapie 7. The Spongiform Vacuole-The Hallmark of Slow Virus Diseases 8. Putative Morphogenesis of Vacuoles from "Abnormal Configuration of Plasma Membranes" 9. Astrocytic Changes 10. Immunohistochemistry of Astrocytic Reaction 11. Microglia in Scrapie 12. Neuroaxonal Dystrophy in Unconventional Slow Virus Disease 13. The Amyloid Plaque 14. Neuronal Degeneration in Unconventional Slow Virus Disorders 15. Tubulovesicular Structures 16. Scrapie-Associated Fibrils.