Itch: Mechanisms and Treatment

1st Edition

E. Carstens, Tasuku Akiyama

CRC Press
Published February 25, 2014
Reference - 494 Pages - 33 Color & 69 B/W Illustrations
ISBN 9781466505438 - CAT# K14566
Series: Frontiers in Neuroscience

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Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain.

Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer.

Composed of contributions from distinguished researchers around the world, the book explores topics such as:

  • Neuropathic itch
  • Peripheral neuronal mechanism of itch
  • The role of PAR-2 in neuroimmune communication and itch
  • Mrgprs as itch receptors
  • The role of interleukin-31 and oncostatin M in itch and neuroimmune communication
  • Spinal coding of itch and pain
  • Spinal microcircuits and the regulation of itch

Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.


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